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Anexinas: implicación en la homeostasis del colesterol, la respuesta inflamatoria y la aterosclerosis

Publicado en:Clinica e Investigacion en Arteriosclerosis. 33 (4): 206-216 - 2021-01-01 33(4), DOI: https://doi.org/10.1016/j.arteri.2020.12.010

Autores: Méndez Barbero, Nerea; Gutiérrez Muñoz, Carmen; Blázquez Serra, Rafael; Martín Ventura, José Luis; Blanco Colio, Luis Miguel

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Resumen

The annexin superfamily consists of 12 proteins with a highly structural homology that binds to phospholipids depending on the availability of Ca2+-dependent. Different studies of overexpression, inhibition, or using recombinant proteins have linked the main function of these proteins to their dynamic and reversible binding to membranes. Annexins are found in multiple cellular compartments, regulating different functions, such as membrane trafficking, anchoring to the cell cytoskeleton, ion channel regulation, as well as pro- or anti-inflammatory and anticoagulant activities. The use of animals deficient in any of these annexins has established their possible functions in vivo, demonstrating that annexins can participate in relevant functions independent of Ca2+ signalling. This review will focus mainly on the role of different annexins in the pathological vascular remodelling that underlies the formation of the atherosclerotic lesion, as well as in the control of cholesterol homeostasis.Copyright © 2021 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

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