Indexado en

Enlace externo

Licencia y uso

Citaciones

Altmetrics

Análisis de autorías institucional

Martin Ventura, Jose LuisAutor o Coautor

Compartir

Fisiopatología del aneurisma de aorta abdominal: biomarcadores y nuevas dianas terapéuticas

Publicado en:Clinica e Investigacion en Arteriosclerosis. 31 (4): 166-177 - 2019-01-01 31(4), DOI: https://doi.org/10.1016/j.arteri.2018.10.002

Autores: Torres Fonseca, Mónica María; Galán Arroyo, María; Martínez, Diego; Cañes, Laia; Roldán Montero, Raquel; Alonso, Judith; Reyero Postigo, Teresa; Orriols, Mar; Méndez Barbero, Nerea; Sirvent, Marc; Blanco Colio, Luis Miguel; Martínez González, José; Martín Ventura, José Luis; Rodríguez, Cristina

Afiliaciones

Resumen

Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease, usually asymptomatic, there is a progressive dilatation of the vascular wall that can lead to its rupture, a fatal phenomenon in more than 80% of cases. The treatment of patients with asymptomatic aneurysms is limited to periodic monitoring with imaging tests, control of cardiovascular risk factors and treatment with statins and antiplatelet therapy. There is no effective pharmacological treatment capable of limiting AAA progression or avoiding their rupture. At present, the aortic diameter is the only marker of risk of rupture and determines the need for surgical repair when it reaches values greater than 5.5cm. This review addresses the main aspects related to epidemiology, risk factors, diagnosis and clinical management of AAA, exposes the difficulties to have good biomarkers of this pathology and describes the strategies for the identification of new therapeutic targets and biomarkers in AAA.Copyright © 2018 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

Palabras clave