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Martin Ventura, Jose LuisAuthor
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Fisiopatología del aneurisma de aorta abdominal: biomarcadores y nuevas dianas terapéuticas

Publicated to:Clinica e Investigacion en Arteriosclerosis. 31 (4): 166-177 - 2019-01-01 31(4), DOI: https://doi.org/10.1016/j.arteri.2018.10.002

Authors: Torres Fonseca, Mónica María; Galán Arroyo, María; Martínez, Diego; Cañes, Laia; Roldán Montero, Raquel; Alonso, Judith; Reyero Postigo, Teresa; Orriols, Mar; Méndez Barbero, Nerea; Sirvent, Marc; Blanco Colio, Luis Miguel; Martínez González, José; Martín Ventura, José Luis; Rodríguez, Cristina

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Abstract

Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease, usually asymptomatic, there is a progressive dilatation of the vascular wall that can lead to its rupture, a fatal phenomenon in more than 80% of cases. The treatment of patients with asymptomatic aneurysms is limited to periodic monitoring with imaging tests, control of cardiovascular risk factors and treatment with statins and antiplatelet therapy. There is no effective pharmacological treatment capable of limiting AAA progression or avoiding their rupture. At present, the aortic diameter is the only marker of risk of rupture and determines the need for surgical repair when it reaches values greater than 5.5cm. This review addresses the main aspects related to epidemiology, risk factors, diagnosis and clinical management of AAA, exposes the difficulties to have good biomarkers of this pathology and describes the strategies for the identification of new therapeutic targets and biomarkers in AAA.Copyright © 2018 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

Keywords
abdominal aortic aneurysmaneurisma de aorta abdominalbiomarcadorbiomarkerfactores de riesgomanejo terapéuticorisk factorsTherapeutic management

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinica e Investigacion en Arteriosclerosis, Q3 Agency Scopus (SJR), its regional focus and specialization in Pharmacology (Medical), give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-10:

  • Scopus: 48
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-10:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 178 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.