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CGR is supported by Miguel Servet program from Instituto de Salud Carlos III (CP20/00066),TMLP was supported by a grant from Instituto de Salud Carlos III (FI19/00178). NPM is supported by a grant from "Programa Estatal de Promocion del Talento y su empleabilidad 2021" (POEJ-00039-18-IBIMA). SM is supported by Nicolas Monardes program from the Consejeria de Salud de la Juntade Andalucia (RC-0008-2021). This work was supported in part by a grant from the Instituto deSalud Carlos III (PI15-01350). This study has been co-funded by FEDER funds ("A way to makeEurope"). Funding for open access charge: Universidad de Malaga/CBUA. CIBER Fisiopatologia dela Obesidad y Nutricion (CIBEROBN) is ISCIII project

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Epigenetic Marks as Predictors of Metabolic Response to Bariatric Surgery: Validation from an Epigenome Wide Association Study

Publicado en:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24 (19): 14778- - 2023-10-01 24(19), DOI: 10.3390/ijms241914778

Autores: Gutierrez-Repiso, Carolina; Cantarero-Cuenca, Antonio; Gonzalez-Jimenez, Andres; Linares-Pineda, Teresa; Pena-Montero, Nerea; Ocana-Wilhelmi, Luis; Tinahones, Francisco J; Morcillo, Sonsoles

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Little is known about the potential role of epigenetic marks as predictors of the resolution of obesity-related comorbidities after bariatric surgery. In this study, 20 patients were classified according to the metabolic improvement observed 6 months after sleeve gastrectomy, based on the diagnosis of metabolic syndrome, into responders if metabolic syndrome reversed after bariatric surgery (n = 10) and non-responders if they had metabolic syndrome bariatric surgery (n = 10). Blood DNA methylation was analyzed at both study points using the Infinium Methylation EPIC Bead Chip array-based platform. Twenty-six CpG sites and their annotated genes, which were previously described to be associated with metabolic status, were evaluated. Cg11445109 and cg19469447 (annotated to Cytochrome P450 2E1 (CYP2E1) gene) were significantly more hypomethylated in the responder group than in the non-responder group at both study points, whilst cg25828445 (annotated to Nucleolar Protein Interacting With The FHA Domain Of MKI67 Pseudogene 3 (NIFKP3) gene) showed to be significantly more hypermethylated in the non-responder group compared to the responder group at both study points. The analysis of the methylation sites annotated to the associated genes showed that CYP2E1 had 40% of the differentially methylated CpG sites, followed by Major Histocompatibility Complex, Class II, DR Beta 1 (HLA-DRB1) (33.33%) and Zinc Finger Protein, FOG Family Member 2 (ZFPM2) (26.83%). Cg11445109, cg19469447 and cg25828445 could have a role in the prediction of metabolic status and potential value as biomarkers of response to bariatric surgery.

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