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CGR is supported by Miguel Servet program from Instituto de Salud Carlos III (CP20/00066),TMLP was supported by a grant from Instituto de Salud Carlos III (FI19/00178). NPM is supported by a grant from "Programa Estatal de Promocion del Talento y su empleabilidad 2021" (POEJ-00039-18-IBIMA). SM is supported by Nicolas Monardes program from the Consejeria de Salud de la Juntade Andalucia (RC-0008-2021). This work was supported in part by a grant from the Instituto deSalud Carlos III (PI15-01350). This study has been co-funded by FEDER funds ("A way to makeEurope"). Funding for open access charge: Universidad de Malaga/CBUA. CIBER Fisiopatologia dela Obesidad y Nutricion (CIBEROBN) is ISCIII project

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Pena-Montero, NereaAuthor

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Epigenetic Marks as Predictors of Metabolic Response to Bariatric Surgery: Validation from an Epigenome Wide Association Study

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24 (19): 14778- - 2023-10-01 24(19), DOI: 10.3390/ijms241914778

Authors: Gutierrez-Repiso, Carolina; Cantarero-Cuenca, Antonio; Gonzalez-Jimenez, Andres; Linares-Pineda, Teresa; Pena-Montero, Nerea; Ocana-Wilhelmi, Luis; Tinahones, Francisco J; Morcillo, Sonsoles

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Abstract

Little is known about the potential role of epigenetic marks as predictors of the resolution of obesity-related comorbidities after bariatric surgery. In this study, 20 patients were classified according to the metabolic improvement observed 6 months after sleeve gastrectomy, based on the diagnosis of metabolic syndrome, into responders if metabolic syndrome reversed after bariatric surgery (n = 10) and non-responders if they had metabolic syndrome bariatric surgery (n = 10). Blood DNA methylation was analyzed at both study points using the Infinium Methylation EPIC Bead Chip array-based platform. Twenty-six CpG sites and their annotated genes, which were previously described to be associated with metabolic status, were evaluated. Cg11445109 and cg19469447 (annotated to Cytochrome P450 2E1 (CYP2E1) gene) were significantly more hypomethylated in the responder group than in the non-responder group at both study points, whilst cg25828445 (annotated to Nucleolar Protein Interacting With The FHA Domain Of MKI67 Pseudogene 3 (NIFKP3) gene) showed to be significantly more hypermethylated in the non-responder group compared to the responder group at both study points. The analysis of the methylation sites annotated to the associated genes showed that CYP2E1 had 40% of the differentially methylated CpG sites, followed by Major Histocompatibility Complex, Class II, DR Beta 1 (HLA-DRB1) (33.33%) and Zinc Finger Protein, FOG Family Member 2 (ZFPM2) (26.83%). Cg11445109, cg19469447 and cg25828445 could have a role in the prediction of metabolic status and potential value as biomarkers of response to bariatric surgery.

Keywords

Bariatric surgeryDna methylationIncreaseMetabolic syndromMetabolic syndromeMethylation

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Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 66/313, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-07:

  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-07:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 9 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.