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Analysis of institutional authors

Rayego-Mateos SAuthorCannata-Ortiz PAuthorRuiz-Ortega MAuthorFernandez-Fernandez BAuthorOrtiz AAuthor

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September 5, 2023
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Article
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STING1 deficiency ameliorates immune-mediated crescentic glomerulonephritis in mice

Publicated to: JOURNAL OF PATHOLOGY. 261 (3): 309-322 - 2023-11-01 261(3), DOI: 10.1002/path.6177

Authors:

García-Giménez, J; Córdoba-David, G; Rayego-Mateos, S; Cannata-Ortiz, P; Carrasco, S; Ruiz-Ortega, M; Fernandez-Fernandez, B; Ortiz, A; Ramos, AM
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Affiliations

Fdn Jimenez Diaz, Inst Invest Sanit, Nephrol & Hypertens Lab, Ave Reyes Catolicos 4, Madrid 28040, Spain - Author
Inst Salud Carlos III ISCIII, RICORS2040, Madrid, Spain - Author
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz - Author
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz , Facultad de Medicina de la Universidad Autónoma de Madrid , Instituto de Salud Carlos III - Author
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz , Instituto de Salud Carlos III - Author
Univ Autonoma Madrid, Dept Pathol, IIS Fdn Jimenez Diaz, Madrid, Spain - Author
Univ Autonoma Madrid, Fac Med, Dept Med, Madrid, Spain - Author
Univ Autonoma Madrid, Fac Med, Dept Pharmacol, Madrid, Spain - Author
Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Cellular Biol Renal Dis Lab, Madrid, Spain - Author
Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Dept Nephrol & Hypertens, Madrid, Spain - Author
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Abstract

Rapidly progressive/crescentic glomerulonephritis (RPGN/CGN) involves the formation of glomerular crescents by maladaptive differentiation of parietal epithelial cells that leads to rapid loss of renal function. The molecular mechanisms of crescent formation are poorly understood. Therefore, new insights into molecular mechanisms could identify alternative therapeutic targets for RPGN/CGN. Analysis of kidney biopsies from patients with RPGN revealed increased interstitial, glomerular, and tubular expression of STING1, an accessory protein of the c-GAS-dependent DNA-sensing pathway, which was also observed in murine nephrotoxic nephritis induced by an anti-GBM antibody. STING1 was expressed by key cell types involved in RPGN and crescent formation such as glomerular parietal epithelial cells, and tubular cells as well as by inflammation accessory cells. In functional in vivo studies, Sting1−/− mice with nephrotoxic nephritis had lower kidney cytokine expression, milder kidney infiltration by innate and adaptive immune cells, and decreased disease severity. Pharmacological STING1 inhibition mirrored these findings. Direct STING1 agonism in parietal and tubular cells activated the NF-κB-dependent cytokine response and the interferon-induced genes (ISGs) program. These responses were also triggered in a STING1-dependent manner by the pro-inflammatory cytokine TWEAK. These results identify STING1 activation as a pathological mechanism in RPGN/CGN and TWEAK as an activator of STING1. Pharmacological strategies targeting STING1, or upstream regulators may therefore be potential alternatives to treat RPGN. © 2023 The Pathological Society of Great Britain and Ireland.
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Keywords

activationagonistscelldiseaseinflammationkidneyrapidly progressive/crescentic glomerulonephritisrecruitmentrenal parietal cellsrenal tubular cellssting1triggerstweakI interferonInflammationRapidly progressive/crescentic glomerulonephritisRenal parietal cellsRenal tubular cellsSting1Tweak

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal of Pathology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 8/88, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pathology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • Google Scholar: 1
  • WoS: 1
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 9.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 9 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (García-Giménez J) and Last Author (Ramos AM).

the author responsible for correspondence tasks has been Ramos AM.

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