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Grant support

The authors thank E. Gabande-Rodriguez and M. Pfeiffer for critical reading and helpful comments on the manuscript. This study was supported by the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI19/855), the European Regional Development Fund (ERDF) and the European Commission through H2020-EU.1.1, European Research Council grant ERC-2016-StG 715322-EndoMitTalk, and the Y2020/BIO-6350 NutriSION-CM synergy grant from Comunidad de Madrid. G.S.-H. is supported by an FPI-UAM grant (Universidad Autonoma de Madrid). M.M.G.H. and J.I.E.-L. are supported by FPU grants (FPU19/02576 and FPU20/04066, respectively), both from Ministerio de Ciencia, Innovacion y Universidades (Spain).

Analysis of institutional authors

Montero Gomez De Las Heras, ManuelAuthorSoto-Heredero, GonzaloCorresponding AuthorMittelbrunn, MariaAuthor
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Review

Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging

Publicated to:Annual Review of Immunology. 41 181-205 - 2023-04-26 41(), DOI: 10.1146/annurev-immunol-101721-064501

Authors: Soto-Heredero, Gonzalo; De las Heras, Manuel M Gomez; Ignacio Escrig-Larena, J; Mittelbrunn, Maria

Affiliations

CSIC, Ctr Biol Mol Severo Ochoa, Homeostasis Tejidos & Organos, Madrid, Spain - Author
Inst Invest Sanitaria Hosp 12 Octubre, Madrid, Spain - Author
Univ Autonoma Madrid, Fac Ciencias, Dept Biol Mol, Madrid, Spain - Author
Univ Autonoma Madrid, Madrid, Spain - Author

Abstract

There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.

Keywords
immunosenescenceinflammationlymphocytesenescenceActivationAgeAntigenCd4(+)Effector functionsExhaustionExpressionImmunosenescenceInflammationLymphocyteMemory phenotypeSenescenceThymus involutionTranscription factor

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Annual Review of Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 3/181, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 19.64, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-13, the following number of citations:

  • WoS: 19
  • Scopus: 27
  • OpenCitations: 24
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 62.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 61 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.75.
  • The number of mentions on the social network X (formerly Twitter): 23 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SOTO HEREDERO, GONZALO) and Last Author (MITTELBRUNN HERRERO, MARIA).

the author responsible for correspondence tasks has been SOTO HEREDERO, GONZALO.