{rfName}
C9

Indexed in

License and use

Citations

66

Altmetrics

Grant support

This work was supported by Fondo de Investigacion Sanitaria (Red de Trastornos Adictivos, RD06/0001/0011), Ministerio de Sanidad y Consumo (Plan Nacional Sobre Drogas, PR61/08-16415), Ministerio de Ciencia e Innovacion (SAF2008-03763 and SAF2011-26818), Grupo de Investigacion UCM-Banco Santander (Grupo 940157) and Accion Especial UCM AE10/07-15503.

Analysis of institutional authors

Gimenez, TAuthor

Share

Publications
>
Article

C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate

Publicated to:GENES BRAIN AND BEHAVIOR. 11 (6): 677-683 - 2012-08-01 11(6), DOI: 10.1111/j.1601-183X.2012.00793.x

Authors: Huertas, E; Buehler, K -M; Echeverry-Alzate, V; Gimenez, T; Lopez-Moreno, J A

Affiliations

Univ Complutense, Fac Psicol, Madrid 28223, Spain - Author
Univ Complutense, Lab Human Expt Psychol, Dept Basic Psychol, Madrid 28223, Spain - Author
Univ Complutense, Psychobiol Lab, Dept Psychobiol, Madrid 28223, Spain - Author

Abstract

Genetic variants that are related to the dopaminergic system have been frequently found to be associated with various neurological and mental disorders. Here, we studied the relationships between some of these genetic variants and some cognitive and psychophysiological processes that are implicated in such disorders. Two single nucleotide polymorphisms were chosen: one in the dopamine D2 receptor gene (rs6277-C957T) and one in the catechol-O-methyltransferase gene (rs4680-Val158Met), which is involved in the metabolic degradation of dopamine. The performance of participants on two long-term memory tasks was assessed: free recall (declarative memory) and mirror drawing (procedural motor learning). Heart rate (HR) was also monitored during the initial trials of the mirror-drawing task, which is considered to be a laboratory middle-stress generator (moderate stress), and during a rest period (low stress). Data were collected from 213 healthy Caucasian university students. The C957T C homozygous participants showed more rapid learning than the T allele carriers in the procedural motor learning task and smaller differences in HR between the moderate- and the low-stress conditions. These results provide useful information regarding phenotypic variance in both healthy individuals and patients.

Keywords

Availability in-vivoCatechol-o-methyltransferaseCognitive functionDopaminergicDrd2 geneGenetic polymorphismHeart rateHuman brainMemoryMirror drawingMirror drawing testParkinsons-diseasePosttraumatic-stress-disorderPredict individual-differencesProcedural memoryRecallStress

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal GENES BRAIN AND BEHAVIOR due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 10/49, thus managing to position itself as a Q1 (Primer Cuartil), in the category Behavioral Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.92, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-13, the following number of citations:

  • WoS: 23
  • Scopus: 24
  • Europe PMC: 19
  • OpenCitations: 23

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 50.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 50 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.