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Grant support

We thank Dr. M. Sefton for editorial assistance. This work has been supported by Grupo de Investigacion Junta de Andalucia CTS113, Consejeria de Salud of the Junta de Andalucia (PI-0036-2014), Fundacion Ramon Areces, and the Departamento Gobernamental de Investigaciones Cientificas y Tecnologicas (DGICYT: BFU2008-01,552 and BFU2011-27,207).

Analysis of institutional authors

Ulecia-Morón, CristinaAuthor

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January 31, 2023
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Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

Publicated to:MOLECULAR NEUROBIOLOGY. 53 (7): 4874-4882 - 2016-09-01 53(7), DOI: 10.1007/s12035-015-9408-7

Authors: Alcocer-Gomez, Elisabet; Ulecia-Moron, Cristina; Marin-Aguilar, Fabiola; Rybkina, Tatyana; Casas-Barquero, Nieves; Ruiz-Cabello, Jesus; Ryffel, Bernhard; Apetoh, Lionel; Ghiringhelli, Francois; Bullon, Pedro; Antonio Sanchez-Alcazar, Jose; Carrion, Angel M.; Cordero, Mario D.;

Affiliations

CIBER Enfermedades Resp, Madrid, Spain - Author
CNRS, UMR7355, Orleans, France - Author
Ctr Georges Francois Leclerc, Dijon, France - Author
Ctr Nacl Invest Cardiovasc, Adv Imaging Unit, Madrid, Spain - Author
INSERM, UMR866, Dijon, France - Author
ISCIII, CIBERER, Seville 41013, Spain - Author
Univ Bourgogne, Dijon, France - Author
Univ Complutense Madrid, Madrid, Spain - Author
Univ Pablo de Olavide CSIC Junta de Andalucia, CABD, Seville 41013, Spain - Author
Univ Pablo de Olavide Sevilla, Dept Fisiol Anat & Biol Celular, Carretera Utrera Km 1, Seville 41013, Spain - Author
Univ Seville Spain, CSIC, Univ Hosp Virgen del Rocio, IBiS Inst Biomed Seville, Seville, Spain - Author
Univ Seville, Fac Med, Hosp Univ Virgen Macarena, Dept Psiquiatria, Seville, Spain - Author
Univ Seville, IBiS Inst Biomed Seville, C Calle Antonio Maura Montaner S-N, Seville 41013, Spain - Author
Univ Seville, Sch Dent, Res Lab, Seville, Spain - Author
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Abstract

Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in animal model of stress-induced depression. Accordingly, we show here that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis. Indeed, NLRP3 deletion or inhibition of microglial activation impairs the stress-induced alterations associated with depression. According to these findings in animal model, the inflammasome could be a target for new therapeutic interventions to prevent depression in patients.

Keywords

depressioninflammasomemicrogliaActivationBrainDepressionHippocampal neurogenesisInflammasomeMajor depressionMediatorMicrogliaPathwayStress

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MOLECULAR NEUROBIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position 25/259, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.63. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 33.17 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-04, the following number of citations:

  • WoS: 112

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 112 (PlumX).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France.