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Analysis of institutional authors

Martín-Gayo ECorresponding Author

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January 2, 2023
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Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers

Publicated to:Frontiers in Immunology. 13 1017164- - 2022-12-07 13(), DOI: 10.3389/fimmu.2022.1017164

Authors: Martin-Gayo, Enrique; Gao, Ce; Calvet-Mirabent, Marta; Ouyang, Zhengyu; Lichterfeld, Mathias; Yu, Xu G G

Affiliations

Brigham & Womens Hosp, Infect Dis Div, Boston, MA 02115 USA - Author
Massachusetts Gen Hosp, Boston, MA 02114 USA - Author
Massachusetts General Hospital - Author
Massachusetts General Hospital , Universidad Autónoma de Madrid - Author
Ragon Inst Massachusetts Gen Hosp MGH, Massachusetts Gen Hosp, Massachusetts Inst Technol MIT & Harvard, Cambridge, MA 02139 USA - Author
Univ Autonoma Madrid, Hosp Univ Princesa, Immunol Unit, Madrid, Spain - Author
Universidad Autónoma de Madrid - Author
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Abstract

Introduction: Spontaneous control of HIV-1 replication in the absence of anti-retroviral therapy (ART) naturally occurs in a small proportion of HIV-1-infected individuals known as elite controllers (EC), likely as a result of improved innate and adaptive immune mechanisms. Previous studies suggest that enhanced cytosolic immune recognition of HIV-1 reverse transcripts in conventional dendritic cells (mDC) from EC enables effective induction of antiviral effector T cell responses. However, the specific molecular circuits responsible for such improved innate recognition of HIV-1 in mDC from these individuals remain unknown. Results and methods: Here, we identified a subpopulation of EC whose mDC displayed higher baseline abilities to respond to intracellular HIV-1 dsDNA stimulation. A computational analysis of transcriptional signatures from such high responder EC, combined with functional studies, suggested cytosolic recognition of HIV-1 dsDNA by cGAS, combined with sensing of viral mRNA by RIG-I after polymerase III-mediated HIV-1 DNA transcription. Discussion: Together, our work identifies collaborative networks of innate sensing pathways that enhance cell-intrinsic abilities of mDC to induce antiviral innate responses against HIV-1; these observations might be useful for the therapeutic induction of effective antiviral immune responses.

Keywords

dna sensorinfectioninnate immunitymyeloid dendritic cellsrna sensorsensorAntiviral agentsCyclic gmp-ampDendritic cellsDna sensorHiv infectionsHiv seropositivityHiv-1HumansInnate immunityMyeloid dendritic cellsNucleotidyltransferasesRna sensor

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers in Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 35/161, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.48, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-08, the following number of citations:

  • WoS: 2
  • Scopus: 1
  • Europe PMC: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.75.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MARTIN GAYO, ENRIQUE) .

the author responsible for correspondence tasks has been MARTIN GAYO, ENRIQUE.