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Analysis of institutional authors

Franco FAuthorDomine MAuthorProvencio MAuthor

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December 1, 2022
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Molecular Divergence upon EGFR-TKI Resistance Could Be Dependent on the Exon Location of the Original EGFR-Sensitizing Mutation

Publicated to:Cancers. 14 (18): 4446- - 2022-09-01 14(18), DOI: 10.3390/cancers14184446

Authors: Serna-Blasco R; Sánchez-Herrero E; Robado de Lope L; Sanz-Moreno S; Rodríguez-Festa A; Ares-Trotta D; Cruz-Bermúdez A; Franco F; Sánchez-Hernández A; Campayo MdJ; García-Girón C; Dómine M; Blasco A; Sánchez JM; Oramas J; Bosch-Barrera J; Sala MA; Sereno M; Romero A; Provencio M

Affiliations

Complejo Asistencial Universitario de Burgos - Author
Fundación Jiménez Díaz - Author
Hospital General Universitario de Valencia - Author
Hospital ICO Girona - Author
Hospital Infanta Sofia - Author
Hospital Provincial Centre de Castelló - Author
Hospital Universitario de Canarias - Author
Hospital Universitario de la Princesa - Author
Hospital Universitario Puerta de Hierro Majadahonda - Author
Hospital Universitario Puerta de Hierro Majadahonda , Atrys Health - Author
Osakidetza, Basurto University Hospital - Author
Pirogov Russian National Research Medical University (RNRMU) - Author
Pirogov Russian National Research Medical University (RNRMU) , Hospital Universitario Puerta de Hierro Majadahonda - Author
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Abstract

Tumor molecular profiling upon disease progression enables investigations of the tumor evolution. Next-generation sequencing (NGS) of liquid biopsies constitutes a noninvasive readily available source of tumor molecular information. In this study, 124 plasma samples from advanced EGFR-positive NSCLC patients, treated with a first-line EGFR tyrosine kinase inhibitor (EGFR-TKI) were collected upon disease progression. The circulating cell-free DNA (cfDNA) was sequenced using the Oncomine Pan-Cancer Cell-Free Assay™. Excluding EGFR mutations, the most frequently mutated gene was TP53 (57.3%), followed by APC (11.3%), FGFR3 (7.3%), and KRAS (5.6%). Different molecular alterations were observed upon disease progression depending on the location of the original EGFR-sensitizing mutation. Specifically, the detection of the p.T790M mutation was significantly associated with the presence of exon 19 mutations in EGFR (Fisher p-value: 0.028). All KRAS activating mutations (n = 8) were detected in tumors with EGFR mutations in exons 18 and 21 (Fisher p-value < 0.001). Similarly, mutations in NRAS and HRAS were more frequently detected in samples from tumors harboring mutations in exons 18 or 21 (Fisher p-value: 0.050 and Fisher p-value: 0.099, respectively). In conclusion, our data suggest that the mechanisms underlying EGFR-TKI resistance could be dependent on the exon location of the original EGFR-sensitizing mutation.

Keywords

egfrkrasngsnsclcEgfrKrasLiquid biopsyNgsNsclc

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cancers due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Oncology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 7.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 5.6.
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Russia.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (PROVENCIO PULLA, MARIANO).