{rfName}
Ef

Indexed in

License and use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Cuadrado-Peñafiel VAuthorPareja-Galeano HCorresponding Author

Share

November 21, 2022
Publications
>
Article

Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial

Publicated to:Nutrients. 14 (21): 4635- - 2022-11-01 14(21), DOI: 10.3390/nu14214635

Authors: Martinez-Ferran, Maria; Cuadrado-Penafiel, Victor; Manuel Sanchez-Andreo, Juan; Villar-Lucas, Marta; Castellanos-Montealegre, Monica; Rubio-Martin, Agustin; Romero-Morales, Carlos; Casla-Barrio, Soraya; Pareja-Galeano, Helios

Affiliations

Hosp 12 Octubre, Madrid 28041, Spain - Author
Hospital Universitario 12 de octubre - Author
Tigers Running Club, Madrid 28009, Spain - Author
Univ Autonoma Madrid, Dept Phys Educ Sport & Human Movement, Madrid 28049, Spain - Author
Univ Castilla La Mancha, Fac Sports Sci, Toledo 45002, Spain - Author
Univ Comillas, Fac Nursing, Madrid 28015, Spain - Author
Univ Europea Madrid, Fac Sports Sci, Madrid 28670, Spain - Author
Univ Isabel I, Fac Hlth Sci, Burgos 09003, Spain - Author
Universidad Autónoma de Madrid - Author
Universidad de Castilla-La Mancha - Author
Universidad Europea de Madrid - Author
Universidad Isabel I , Universidad Europea de Madrid - Author
Universidad Pontificia Comillas - Author
See more

Abstract

Considering the existing controversy over the possible role of acute antioxidant vitamins in reducing exercise-induced muscle damage (EIMD), this doubled-blind, randomized and controlled trial aimed to determine whether supplementation with vitamins C and E could mitigate the EIMD in endurance-trained runners (n = 18). The exercise protocol involved a warm-up followed by 6 to 8 bouts of 1 km running at 75% maximum heart rate (HRmax). Two hours before the exercise protocol, participants took the supplementation with vitamins or placebo, and immediately afterwards, blood lactate, rate of perceived exertion and performance were assessed. At 24 h post-exercise, CK, delayed onset muscle soreness and performance were determined (countermovement jump, squat jump and stiffness test). The elastic index and vertical stiffness were calculated using a stiffness test. Immediately after the exercise protocol, all participants showed improved maximum countermovement jump, which only persisted after 24 h in the vitamin group (p < 0.05). In both groups, squat jump height was significantly greater (p < 0.05) immediately after exercise and returned to baseline values after 24 h. The elastic index increased in the vitamin group (p < 0.05), but not in the placebo group. In both groups, lactate levels increased from pre- to immediately post-exercise (p < 0.05), and CK increased from pre- to 24 h post-exercise (p < 0.05). No significant differences between groups were observed in any of the variables (p > 0.05). Vitamin C and E supplementation does not seem to help with EIMD in endurance-trained individuals.

Keywords

adaptationsalpha-tocopherolantioxidantsascorbic acidathletic performanceimpactmechanismsmuscle damageoxidative stressperformancerecoverysorenesstocopherolsAntioxidantsAscorbic acidAthletic performanceDietary supplementsDouble-blind methodHumansLactatesLipid-peroxidationMuscle damageMuscle, skeletalMyalgiaTocopherolsVitamin eVitamins

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 17/88, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.55. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.18 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 7.66 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 11
  • Scopus: 12
  • Europe PMC: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 65.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 83 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.05.
  • The number of mentions on the social network X (formerly Twitter): 17 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/707130

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (PAREJA GALEANO, HELIOS).

the author responsible for correspondence tasks has been PAREJA GALEANO, HELIOS.