{rfName}
MD

Indexed in

License and use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Martin-Ventura JlAuthor

Share

Publications
>
Article

MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses

Publicated to:Cell Reports. 41 (2): 111468- - 2022-10-11 41(2), DOI: 10.1016/j.celrep.2022.111468

Authors: Martos-Folgado I; del Monte-Monge A; Lorenzo C; Busse CE; Delgado P; Mur SM; Cobos-Figueroa L; Escolà-Gil JC; Martín-Ventura JL; Wardemann H; Ramiro AR

Affiliations

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas , Hospital de La Santa Creu I Sant Pau - Author
Centro Nacional de Investigaciones Cardiovasculares Carlos III - Author
Centro Nacional de Investigaciones Cardiovasculares Carlos III , Grupo de Manufactura Avanzada con Láser del Centro Láser (UPM) - Author
Centro Nacional de Investigaciones Cardiovasculares Carlos III , Pfizer Inc. - Author
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain - Author
Ctr Nacl Invest Cardiovasculares CNIC, B Lymphocyte Biol Lab, Madrid, Spain - Author
German Canc Res Ctr, Div Cell Immunol B, Heidelberg, Germany - Author
German Cancer Research Center - Author
GIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain - Author
Grp Manufactura Avanzada Laser Ctr Laser UPM, Madrid, Spain - Author
Hosp La Santa Creu & St Pau, Inst Recerca, Barcelona, Spain - Author
Inst Salud Carlos III, Unidad Presentac & Regulac Inmunes, Madrid, Spain - Author
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz , Centro de Investigación en Red en Enfermedades Cardiovasculares - Author
Pfizer SLU, Med Dept, Madrid, Spain - Author
Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, Madrid, Spain - Author
Univ Autonoma, Vasc Pathol Lab, IIS Fdn Jimenez Diaz, Madrid, Spain - Author
See more

Abstract

Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1fl/fl Aicda-Cre+/ki Ldlr−/− pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis.

Keywords

antibodyatherosclerosisb cellcoronary-artery-diseasecp: immunologygerminal centerhigh titersimmunizationmda-ldlmemory boxidation-specific epitopesoxidized ldlreceptor-deficient micet-cellsAntibodyAtherosclerosisB cellCp: immunologyGerminal centerLow-density-lipoproteinMda-ldlVaccine

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cell Reports due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 32/191, thus managing to position itself as a Q1 (Primer Cuartil), in the category Cell Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.97, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-22, the following number of citations:

  • WoS: 4
  • Scopus: 13

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 13.7.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 22 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany; United States of America.