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Analysis of institutional authors

Márquez-Valadez BCorresponding AuthorLlorens-Martín MCorresponding Author

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September 1, 2022
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Progression of Alzheimer's disease parallels unusual structural plasticity of human dentate granule cells

Publicated to:Acta Neuropathologica Communications. 10 (1): 125-125 - 2022-08-29 10(1), DOI: 10.1186/s40478-022-01431-7

Authors: Marquez-Valadez, B; Rabano, A; Llorens-Martin, M

Affiliations

Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain. m.llorens@csic.es. - Author
CIEN Fdn, Neuropathol Dept, Madrid, Spain - Author
Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain - Author
Neuropathology Department, CIEN Foundation, Madrid, Spain. - Author
Univ Autonoma Madrid UAM, Spanish Res Council CSIC, Ctr Biol Mol Severo Ochoa CBMS0, Dept Mol Neuropathol, Campus Cantoblanco,C Nicolas Cabrera 1, Madrid 28049, Spain - Author
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Abstract

Alzheimer´s disease (AD), the most common form of dementia in industrialized countries, severely targets the hippocampal formation in humans and mouse models of this condition. The adult hippocampus hosts the continuous addition of new dentate granule cells (DGCs) in numerous mammalian species, including humans. Although the morphology and positioning of DGCs within the granule cell layer (GCL) match their developmental origin in rodents, a similar correlation has not been reported in humans to date. Our data reveal that DGCs located in inner portions of the human GCL show shorter and less complex dendrites than those found in outer portions of this layer, which are presumably generated developmentally. Moreover, in AD patients, DGCs show early morphological alterations that are further aggravated as the disease progresses. An aberrantly increased number of DGCs with several primary apical dendrites is the first morphological change detected in patients at Braak-Tau I/II stages. This alteration persists throughout AD progression and leads to generalized dendritic atrophy at late stages of the disease. Our data reveal the distinct vulnerability of several morphological characteristics of DGCs located in the inner and outer portions of the GCL to AD and support the notion that the malfunction of the hippocampus is related to cognitive impairments in patients with AD.

Keywords

AdultAlzheimer diseaseAlzheimer's diseaseAnimalsDendritesDentate granule cellsDentate gyrusGolgi-cox stainingHippocampusHumansMammalsMiceMorphological alterationsNeurogenesisNeurons

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acta Neuropathologica Communications due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 34/272, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.73. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.46 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 3.12 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-04, the following number of citations:

  • WoS: 6
  • Scopus: 6
  • Europe PMC: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 52.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 52 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 30.4.
  • The number of mentions on the social network X (formerly Twitter): 41 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MARQUEZ VALADEZ, BERENICE) and Last Author (LLORENS MARTIN, MARIA VICTORIA).

the authors responsible for correspondence tasks have been MARQUEZ VALADEZ, BERENICE and LLORENS MARTIN, MARIA VICTORIA.