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Grant support

Supported by the European Research Council (ERC-CoG-2020-101001916), Spain's Ministry of Economy and Competitiveness (PID2020-113007RB-I00, SAF-2017-82185-R, and RYC-2015-171899), the Alzheimer's Association (2015-NIRG-340709, AARG-17-528125, and AARG-17-528125-RAPID), the Association for Frontotemporal Degeneration (2016 Basic Science Pilot Grant Award), and the Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED, Spain) (M.Ll.-M.); a Universidad Autonoma de Madrid doctoral fellowship (FPI-UAM 2017 program) (J.T.R.); a Fundacion Tatiana Perez de Guzman 2018 neuroscience doctoral fellowship (E.P.M.J.); a Formacion de Personal Investigador (FPI) contract, associated with grant SAF-2017-82185-R to M.Ll.-M., supported by Spain's Ministry for Economy and Competitiveness grant PRE2018-085233 (M.F.G.); Spain's Ministry of Economy and Competitiveness award "Subvenciones para la promocion de empleo joven e Implantacion de la garantia juvenil en I+D+i 2018" (PEJ2018-001725-A) and Alzheimer's Association grant AARG-17-528125-RAPID to M.Ll.-M. (C.B.R.M.); Consejo Nacional de Ciencia y Tecnologia (CONACYT) of Mexican Government (CVU 385084) and Secretaria de Educacion, Ciencia Tecnologia e Innovacion (SECTEI) de la Ciudad de Mexico (CDMX) postdoctoral fellowships (B.M.V.); and institutional grants to CBMSO from the Fundacion Ramon Areces and Banco de Santander.

Analysis of institutional authors

Terreros-Roncal, JAuthorMarquez-Valadez, BAuthorLlorens-Martin, MCorresponding Author

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August 5, 2022
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Editorial Material
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Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

Publicated to:SCIENCE. 376 (6590): eabn7270- - 2022-04-15 376(6590), DOI: 10.1126/science.abn7270

Authors: Terreros-Roncal, J; Moreno-Jimenez, E P; Flor-Garcia, M; Rodriguez-Moreno, C B; Trinchero, M F; Marquez-Valadez, B; Cafini, F; Rabano, A; Llorens-Martin, M

Affiliations

CIEN Fdn, Neuropathol Dept, Madrid, Spain - Author
Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain - Author
Leloir Inst IIBBA CONICET, Lab Neuronal Plast, Buenos Aires, DF, Argentina - Author
Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Dept Mol Neuropathol, Spanish Res Council CSIC, Madrid, Spain - Author
Univ Autonoma Madrid, Fac Sci, Dept Mol Biol, Madrid, Spain - Author
Univ Europea Madrid, Fac Biomed & Hlth Sci, Madrid, Spain - Author
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Abstract

Rakic and colleagues challenge the use of extensively validated adult hippocampal neurogenesis (AHN) markers and postulate an alternative interpretation of some of the data included in our study. In Terreros-Roncal et al., reconstruction of the main stages encompassed by human AHN revealed enhanced vulnerability of this phenomenon to neurodegenerative diseases. Here, we clarify points and ambiguities raised by these authors.

Keywords

AdultBiological markerBiomarkersDegenerative diseaseHippocampusHumanHumansNervous system developmentNeurodegenerative diseasesNeurogenesisPhysiology

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal SCIENCE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 2/73, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.89, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-04, the following number of citations:

  • WoS: 1
  • Scopus: 2
  • Europe PMC: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 105.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 105 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 5.7.
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (TERREROS RONCAL, JULIA) and Last Author (LLORENS MARTIN, MARIA VICTORIA).

the author responsible for correspondence tasks has been LLORENS MARTIN, MARIA VICTORIA.