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This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI19/00631 and co-funded by the European Union.

Analysis of institutional authors

Roman, MtaCorresponding AuthorJimenez-Yuste, VAuthor

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June 13, 2022
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Acquired Haemophilia A: A 15-Year Single-Centre Experience of Demography, Clinical Features and Outcome

Publicated to:Journal of Clinical Medicine. 11 (10): 2721- - 2022-05-01 11(10), DOI: 10.3390/jcm11102721

Authors: Guerrero Camacho, Raisa; Alvarez Roman, Maria Teresa; Butta Coll, Nora; Zagrean, Damaris; Rivas Pollmar, Isabel; Martin Salces, Monica; Gasior Kabat, Mercedes; Jimenez-Yuste, Victor

Affiliations

Blackpool Teaching Hosp NHS Fdn Trust, Blackpool FY3 8NR, England - Author
Hosp Univ La Paz, Serv Hematol & Hemoterapia, Paseo La Castellana 231, Madrid 28046, Spain - Author
IdiPAZ, Coagulopathies & Haemostasis Disorders Grp, Paseo Castellana 231, Madrid 28046, Spain - Author
Univ Autonoma Madrid, Fac Med, Arzobispo Morcillo 4, E-28029 Madrid, Spain - Author

Abstract

Acquired haemophilia A (AHA) is a rare severe bleeding disorder resulting from the production of autoantibodies directed against coagulation factor VIII. At presentation, bleeding events can be severe, and an early diagnosis and treatment are of major importance. The current study aims to analyse the treated patients who have been diagnosed with AHA for a better understanding of our population and treatment outcome. We conducted a retrospective study with 26 patients who had been diagnosed with AHA and who were treated in our hospital between January 2006 and January 2021. The patients ranged in age from 30 to 85 years old: 46.10% were men, 46.10% had no known underlying condition, 27% had an underlying malignancy, 7.60% presented with other diseases: psoriatic arthritis and Paget's disease, and 19.30% presented with AHA during puerperium. All of the patients had bleeding events and were treated with bypass agents for this as well as with immunosuppressive therapy to eradicate the inhibitor. A total of 53.80% of the patients had major bleeding. Sixty-nine percent of the patients achieved complete remission, but 26.90% died during the follow-up, although bleeding was not the cause of death in any of these cases. Our observations underline the importance of clinical suspicion and early referral to centres with experience and laboratory facilities for managing AHA.

Keywords

acquireddemographyhaemophilia aAcquiredCohortDemographyDiagnosisFactor-viiiHaemophilia aInhibitorsManagementPresentationRituximabSurveillance

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal of Clinical Medicine due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.36, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 4.02 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 5
  • Scopus: 6
  • Europe PMC: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/713893

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (JIMENEZ YUSTE, VICTOR MANUEL).

the author responsible for correspondence tasks has been ALVAREZ ROMAN, MARIA TERESA.