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Analysis of institutional authors

García-Escudero V.Corresponding Author
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Review

What’s in a Gene? The Outstanding Diversity of MAPT

Publicated to:Cells. 11 (5): 840- - 2022-03-01 11(5), DOI: 10.3390/cells11050840

Authors: Ruiz-Gabarre D; Carnero-Espejo A; Ávila J; García-Escudero V

Affiliations

CIBER Enfermedades Neurodegenerativas , CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM) - Author
Ctr Biol Mol Severo Ochoa UAM CSIC, Madrid 28049, Spain - Author
Inst Salud Carlos III, Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid 28031, Spain - Author
Univ Autonoma Madrid UAM, Grad Program Neurosci, Madrid 28029, Spain - Author
Univ Autonoma Madrid UAM, Sch Med, Anat Histol & Neurosci Dept, Madrid 28029, Spain - Author
Universidad Autónoma de Madrid - Author
Universidad Autónoma de Madrid , CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM) - Author
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Abstract

Tau protein is a microtubule-associated protein encoded by the MAPT gene that carries out a myriad of physiological functions and has been linked to certain pathologies collectively termed tauopathies, including Alzheimer’s disease, frontotemporal dementia, Huntington’s disease, progressive supranuclear palsy, etc. Alternative splicing is a physiological process by which cells generate several transcripts from one single gene and may in turn give rise to different proteins from the same gene. MAPT transcripts have been proven to be subjected to alternative splicing, generating six main isoforms in the central nervous system. Research throughout the years has demonstrated that the splicing landscape of the MAPT gene is far more complex than that, including at least exon skipping events, the use of 3′ and 5′ alternative splice sites and, as has been recently discovered, also intron retention. In addition, MAPT alternative splicing has been showed to be regulated spatially and developmentally, further evidencing the complexity of the gene’s splicing regulation. It is unclear what would drive the need for the existence of so many isoforms encoded by the same gene, but a wide range of functions have been ascribed to these Tau isoforms, both in physiology and pathology. In this review we offer a comprehensive up-to-date exploration of the mechanisms leading to the outstanding diversity of isoforms expressed from the MAPT gene and the functions in which such isoforms are involved, including their potential role in the onset and development of tauopathies such as Alzheimer’s disease.

Keywords
alternative splicingalzheimer's diseasealzheimer’s diseaseexpressionfull-length tauintron retentionmaptmessenger-rnamicrotubule-bindingnucleocytoplasmic transportproline-rich regionprotein-tauregulated exontau proteinAlternative splicingAlzheimer’s diseaseIntron retentionMaptMolecular-weight tauTau protein

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cells due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry, Genetics and Molecular Biology (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.27. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.58 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 4.25 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-09, the following number of citations:

  • WoS: 8
  • Scopus: 17
  • Europe PMC: 9
  • OpenCitations: 14
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 53.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 53 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/707618
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Ruiz-Gabarre D) and Last Author (GARCÍA-ESCUDERO BARRERAS, MARÍA VEGA).

the authors responsible for correspondence tasks have been Avila J and GARCÍA-ESCUDERO BARRERAS, MARÍA VEGA.