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Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was also supported in part by CIBERCV, CIBERESP and Grants: PIE16/00022, PI17/1709, PI19/00948, PI20/144 from the Instituto de Salud Carlos III (co-supported by the European Regional Development Fund `Investing in your future'). CD-V has a Talent Attraction Contract ("Contrato Atraccion de Talento") from the Regional Government of the Madrid Community/IMDEA Food.

Analysis of institutional authors

Laclaustra, MAuthorGuallar-Castillon, PCorresponding AuthorDonat-Vargas, CCorresponding Author

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March 22, 2022
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The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium

Publicated to:EUROPEAN JOURNAL OF NUTRITION. 61 (5): 2697-2709 - 2022-08-01 61(5), DOI: 10.1007/s00394-022-02823-0

Authors: Montero Salazar, Henry; Mendonca, Raquel de Deus; Laclaustra, Martin; Moreno-Franco, Belen; Akesson, Agneta; Guallar-Castillon, Pilar; Donat-Vargas, Carolina;

Affiliations

Hosp Univ Miguel Servet, Inst Invest Sanitaria IIS Aragon, Zaragoza, Spain - Author
IMDEA Food Inst, Madrid, Spain - Author
Inst Salud Carlos III, CIBERCV CIBER Cardiovasc, Madrid, Spain - Author
Inst Salud Carlos III, CIBERESP CIBER Epidemiol & Publ Hlth, Madrid, Spain - Author
Karolinska Inst, Inst Environm Med IMM, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden - Author
Univ Autonoma Madrid, Dept Prevent Med & Publ Hlth & Microbiol, CEI UAM CSIC IdiPaz, Madrid, Spain - Author
Univ Fed Ouro Preto, Dept Clin & Social Nutr, Sch Nutr, Ouro Preto, Brazil - Author
Univ Zaragoza, Dept Med, Zaragoza, Spain - Author
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Abstract

Purpose It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62-1.02; P trend 0.094) and femoral (0.62: 0.48-0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46-0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55-1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62-1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.

Keywords

coronary calciumcross-sectional cohort studyflavonoidsred winestilbenesArtery calciumCardiovascular-diseaseConsumptionCoronary calciumCross-sectional cohort studyEventsFlavonoidsFood-frequency questionnairePolyphenol intakePopulationQuantificationRed wineResveratrolRiskStilbenesSubclinical coronary atherosclerosis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EUROPEAN JOURNAL OF NUTRITION due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.09. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.18 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 6.5 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-09, the following number of citations:

  • WoS: 9
  • Scopus: 14
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 45.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 41 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 8.8.
  • The number of mentions on the social network X (formerly Twitter): 19 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/703019

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil; Sweden.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Salazar, HM) and Last Author (DONAT VARGAS, CAROLINA).

the authors responsible for correspondence tasks have been GUALLAR CASTILLON, MARIA PILAR and DONAT VARGAS, CAROLINA.