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Grant support

This study was supported by the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI16/188, PI19/855), the European Regional Development Fund (ERDF), and the European Commission through H2020-EU.1.1 and European Research Council grant ERC-2016-StG 715322-EndoMitTalk. This work was partially supported by Comunidad de Madrid (S2017/BMD-3867 RENIM-CM), co-financed by European Structural and Investment Fund. M. Mittelbrunn is supported by the Miguel Servet Program (CP 19/014, Fundacion de Investigacion del Hospital 12 de Octubre). J. Oller and E. Gabande-Rodriguez are supported by Juan de la Cierva (IJC2019-040152-I and IJC2018-036850-I respectively). Support was also provided by Ministerio de Ciencia e Innovacion grants (RTI2018-099246-B-I00, Comunidad de Madrid and Fondo Social Europeo funds (AORTASANA-CM; J. Miguel Redondo), J. Miguel Redondo was also funded by Fundacion La Caixa (HR18-00068), The Marfan Foundation USA and the CIBER-CV of Ministerio de Ciencia e Innovacion (CB16/11/00264).

Analysis of institutional authors

Oller JCorresponding AuthorGabandé-Rodríguez EAuthorMartin-Ventura JlAuthorMittelbrunn MCorresponding Author
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Article

Rewiring Vascular Metabolism Prevents Sudden Death due to Aortic Ruptures

Publicated to:ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 42 (4): 462-469 - 2022-04-01 42(4), DOI: 10.1161/ATVBAHA.121.317346

Authors: Oller, Jorge; Gabande-Rodriguez, Enrique; Roldan-Montero, Raquel; Jesus Ruiz-Rodriguez, Maria; Miguel Redondo, Juan; Luis Martin-Ventura, Jose; Mittelbrunn, Maria

Affiliations

Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain (J.O., E.G.-R., M.M.). - Author
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain (J.O., R.R.-M. M.J.R.-R., J.M.R., J.L.M.-V.). - Author
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.J.R.-R., J.M.R., J.L.M.-V.). - Author
Ctr Biol Mol Severo Ochoa, Immunometab & Inflammat Lab, C Nicolas Cabrera 1, Madrid 28049, Spain - Author
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain - Author
Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid, Spain - Author
Fdn Jimenez Diaz, Inst Invest Sanitaria, Madrid, Spain - Author
Hosp 12 Octubre i 12, Inst Invest Sanitaria, Madrid, Spain - Author
Instituto de Investigación Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G.-R., M.M.). - Author
Instituto de Investigación Sanitaria Fundación Jimenez Diaz, Madrid, Spain (R.R.-M.). - Author
Univ Autonoma Madrid UAM, Ctr Biol Mol Severo Ochoa CBMSO, Consejo Super Invest Cient CSIC, Madrid, Spain - Author
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Abstract

The goal of this study was to determine whether boosting mitochondrial respiration prevents the development of fatal aortic ruptures triggered by atherosclerosis and hypertension.Ang-II (angiotensin-II) was infused in ApoE (Apolipoprotein E)-deficient mice fed with a western diet to induce acute aortic aneurysms and lethal ruptures.We found decreased mitochondrial respiration and mitochondrial proteins in vascular smooth muscle cells from murine and human aortic aneurysms. Boosting NAD levels with nicotinamide riboside reduced the development of aortic aneurysms and sudden death by aortic ruptures.Targetable vascular metabolism is a new clinical strategy to prevent fatal aortic ruptures and sudden death in patients with aortic aneurysms.

Keywords
aneurysmsaortic ruptureatherosclerosisdiseasesdnaglycolysismitochondriamitochondrial respirationpathogenesisvascular metabolismAngiotensin iiAnimalsAortic aneurysmAortic ruptureAtherosclerosisDeath, suddenDeficientDnaDna, mitochondriaGlycolysisGoalHumansHypertensionMiceMitochondriaMitochondrial proteinsMitochondrial respirationRespirationVascular metabolism

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 5/68, thus managing to position itself as a Q1 (Primer Cuartil), in the category Peripheral Vascular Disease. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.26. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.26 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 10.93 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-13, the following number of citations:

  • WoS: 10
  • Scopus: 14
  • Europe PMC: 6
  • OpenCitations: 13
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 30.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 30 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 19.05.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 30 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (OLLER PEDROSA, JORGE) and Last Author (MITTELBRUNN HERRERO, MARIA).

the authors responsible for correspondence tasks have been OLLER PEDROSA, JORGE and MITTELBRUNN HERRERO, MARIA.