{rfName}
Ex

Indexed in

License and use

Citations

137

Altmetrics

Grant support

This study was funded by Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Italy, and by Regione Lombardia. A contribution was also provided by Lega Lombarda Fibrosi Cistica.

Analysis of institutional authors

Salice, ValentinaAuthor

Share

February 8, 2022
Publications
>
Article
No

Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation

Publicated to:TRANSPLANT INTERNATIONAL. 27 (6): 553-561 - 2014-01-01 27(6), DOI: 10.1111/tri.12295

Authors: Valenza, Franco; Rosso, Lorenzo; Coppola, Silvia; Froio, Sara; Palleschi, Alessandro; Tosi, Davide; Mendogni, Paolo; Salice, Valentina; Ruggeri, Giulia M.; Fumagalli, Jacopo; Villa, Alessandro; Nosotti, Mario; Santambrogio, Luigi; Gattinoni, Luciano;

Affiliations

Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dipartimento Anestesia Rianimaz Intens & Subinten, Milan, Italy - Author
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Unita Operat Chirurg Torac, Milan, Italy - Author
Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20122 Milan, MI, Italy - Author

Abstract

This paper describes the initial clinical experience of ex vivo lung perfusion (EVLP) at the Fondazione Ca' Granda in Milan between January 2011 and May 2013. EVLP was considered if donor PaO2/FiO(2) was below 300mmHg or if lung function was doubtful. Donors with massive lung contusion, aspiration, purulent secretions, pneumonia, or sepsis were excluded. EVLP was run with a low-flow, open atrium and low hematocrit technique. Thirty-five lung transplants from brain death donors were performed, seven of which after EVLP. EVLP donors were older (54 +/- 9years vs. 40 +/- 15years, EVLP versus Standard, P<0.05), had lower PaO2/FiO(2) (264 +/- 78mmHg vs. 453 +/- 119mmHg, P<0.05), and more chest X-ray abnormalities (P<0.05). EVLP recipients were more often admitted to intensive care unit as urgent cases (57% vs. 18%, P=0.05); lung allocation score at transplantation was higher (79 [40-84] vs. 39 [36-46], P<0.05). After transplantation, primary graft dysfunction (PGD(72) grade 3, 32% vs. 28%, EVLP versus Standard, P=1), mortality at 30days (0% vs. 0%, P=1), and overall survival (71% vs. 86%, EVLP versus Standard P=0.27) were not different between groups. EVLP enabled a 20% increase in available donor organs and resulted in successful transplants with lungs that would have otherwise been rejected (ClinicalTrials.gov number: NCT01967953).

Keywords

brain deathex vivo lung perfusion organ regenerationlung transplantationmarginal donor criteriaBrain deathBrain-deathClinical transplantationEx vivo lung perfusion organ regenerationExperienceExtended criteria donorsFlowGlucoseGraft dysfunctionLung transplantationMarginal donor criteriaOutcomeOutcomesPressureRed-blood-cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal TRANSPLANT INTERNATIONAL due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position 50/197, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Surgery. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Transplantation.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.18. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.36 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 21.38 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-03, the following number of citations:

  • WoS: 62
  • Scopus: 65

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 117.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 128 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 19.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.