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Analysis of institutional authors

Martínez-Fernández LAuthor

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December 20, 2021
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Electron holes in g-quadruplexes: The role of adenine ending groups

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22 (24): 13436- - 2021-12-01 22(24), DOI: 10.3390/ijms222413436

Authors: Balanikas E; Martinez-Fernandez L; Baldacchino G; Markovitsi D

Affiliations

Univ Autonoma Madrid, Fac Ciencias, Dept Quim, Modulo 13,Campus Excelencia UAM CSIC, Madrid 28049, Spain - Author
Univ Autonoma Madrid, IADCHEM Inst Adv Res Chem, Modulo 13,Campus Excelencia UAM CSIC, Madrid 28049, Spain - Author
Univ Paris Saclay, CNRS, CEA, LIDYL, F-91191 Gif Sur Yvette, France - Author
Universidad Autónoma de Madrid - Author
Université Paris-Saclay - Author
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Abstract

The study deals with four-stranded DNA structures (G-Quadruplexes), known to undergo ionization upon direct absorption of low-energy UV photons. Combining quantum chemistry calculations and time-resolved absorption spectroscopy with 266 nm excitation, it focuses on the electron holes generated in tetramolecular systems with adenine groups at the ends. Our computations show that the electron hole is placed in a single guanine site, whose location depends on the position of the adenines at the 3′ or 5′ ends. This position also affects significantly the electronic absorption spectrum of (G+ )• radical cations. Their decay is highly anisotropic, composed of a fast process (<2 µs), followed by a slower one occurring in ~20 µs. On the one hand, they undergo deprotonation to (G-H2)• radicals and, on the other, they give rise to a reaction product absorbing in the 300–500 nm spectral domain.

Keywords

absorptiondensity functionalsdeprotonationdna-damageelectron holesg-quadruplexesguanineguanine radicalsionizationlaser photolysisoxidationoxidative damagephotoionizationquantum chemistrystatestime-resolved spectroscopyCharge-transportElectron holesG-quadruplexesGuanine radicalsOxidative damagePhotoionizationQuantum chemistryTime-resolved spectroscopy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/297, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-04:

  • WoS: 2
  • Scopus: 2
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 4.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/704468

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France.