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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Flandes JCorresponding Author

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November 4, 2021
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Transbronchial biopsy results according to diffuse interstitial lung disease classification. Cryobiopsy versus forceps: MULTICRIO study

Publicated to:PLoS ONE. 15 (9 September): e0239114-e0239114 - 2020-09-01 15(9 September), DOI: 10.1371/journal.pone.0239114

Authors: Pajares V, Núñez-Delgado M, Bonet G, Pérez-Pallarés J, Martínez R, Cubero N, Zabala T, Cordovilla R, Flandes J, Disdier C, Torrego A, MULTICRIO Group researchers

Affiliations

Hospital Álvaro Cunqueiro - Author
Hospital Clínico Universitario de Salamanca - Author
Hospital de Galdakao - Author
Hospital de La Santa Creu I Sant Pau , Biomedical Research Institute San Pau (IIB Sant Pau) - Author
Hospital Universitari de Bellvitge - Author
Hospital Universitari I Politècnic la Fe - Author
Hospital Universitario de Santa Lucía - Author
Hospital Universitario Fundacion Jimenez Diaz - Author
Respiratory Medicine - Author
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Abstract

Background In recent years, transbronchial cryobiopsy (TBCB) has come to be increasingly used in interventional pulmonology units as it obtains larger and better-quality samples than conventional transbronchial lung biopsy (TBLB) with forceps. No multicenter studies have been performed, however, that analyse and compare TBCB and TBLB safety and yield according to the interstitial lung disease (ILD) classification. Objectives We compared the diagnostic yield and safety of TBCB with cryoprobe sampling versus conventional TBLB forceps sampling in the same patient. Method Prospective multicenter clinical study of patients with ILD indicated for lung biopsy. Airway management with orotracheal tube, laryngeal mask and rigid bronchoscope was according to the protocol of each centre. All procedures were performed using fluoroscopy and an occlusion balloon. TBLB was followed by TBCB. Complications were recorded after both TBLB and TBCB. Results Included were 124 patients from 10 hospitals. Airway management was orotracheal intubation in 74% of cases. Diagnostic yield according to multidisciplinary committee results for TBCB was 47.6% and for TBLB was 19.4% (p<0.0001). Diagnostic yield was higher for TBCB compared to TBLB for two groups: idiopathic interstitial pneumonias (IIPs) and ILD of known cause or association (OR 2.5; 95% CI: 1.4–4.2 and OR 5.8; 95% CI: 2.3–14.3, respectively). Grade 3 (moderate) bleeding after TBCB occurred in 6.5% of patients compared to 0.8% after conventional TBLB. Conclusions Diagnostic yield for TBCB was higher than for TBLB, especially for two disease groups: IIPs and ILD of known cause or association. The increased risk of bleeding associated with TBCB confirms the need for safe airway management and prophylactic occlusion-balloon use.

Keywords

Administração pública e de empresas, ciências contábeis e turismoAdministração, ciências contábeis e turismoAgricultural and biological sciences (miscellaneous)AnthropologyAntropologia / arqueologiaArchaeologyArquitetura, urbanismo e designAstronomia / físicaBiochemistry, genetics and molecular biology (miscellaneous)BiodiversidadeBiologyBiotecnologíaCiência da computaçãoCiência de alimentosCiência política e relações internacionaisCiências agrárias iCiências ambientaisCiências biológicas iCiências biológicas iiCiências biológicas iiiCiências sociais aplicadas iComunicação e informaçãoDemographyDireitoEconomiaEducaçãoEducação físicaEnfermagemEngenharias iEngenharias iiEngenharias iiiEngenharias ivEnsinoEnvironmental studiesFarmaciaGeneral agricultural and biological sciencesGeneral biochemistry,genetics and molecular biologyGeneral medicineGeociênciasGeografíaHistoriaHistory & philosophy of scienceHuman geography and urban studiesInterdisciplinarInterdisciplinary research in the social sciencesLetras / linguísticaLinguística e literaturaMatemática / probabilidade e estatísticaMateriaisMedicina iMedicina iiMedicina iiiMedicina veterinariaMedicine (miscellaneous)MultidisciplinaryMultidisciplinary sciencesNutriçãoOdontologíaPlanejamento urbano e regional / demografiaPsicologíaPsychologyQuímicaSaúde coletivaServiço socialSociologíaSociologyZootecnia / recursos pesqueiros

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLoS ONE due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 9.39, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 19
  • Scopus: 20

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 50.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 64 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 82% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

the author responsible for correspondence tasks has been FLANDES ALDEYTURRIAGA, FRANCISCO JAVIER.