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Grant support

A. S. acknowledges the support from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 895809 (MONOCLE). Work at the Molecular Foundry was supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC0205CH11231. E. X. is grateful for a Juan de la Cierva Formacion scholarship (FJC2018-036734-I). P. R.-S. is grateful for a Juan de la Cierva Incorporacion scholarship (IJC2019-041915-I). B. R. acknowledges support from RMIT University (VC Fellowships program) and the Australian Research Council (DE200100985). D. M.-G. Acknowledges "Fundacion para la investigacion biomedica del Hospital Ramon y Cajal" (FIBioHRyC), and the European Commission Horizon 2020 project NanoTBTech (grant number: 801305) for postdoctoral funding. R. M. acknowledges the support of the European Commission through the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement No. 797945 (LANTERNS). Work supported by Ministerio de Ciencia, Innovacion y Universidades of Spain under project PID2019-106211RB-I00 (NANONERV).

Analysis of institutional authors

Skripka, AAuthorMarin, RAuthorXimendes, EAuthorDel Rosal, BAuthorJaque, DCorresponding AuthorRodriguez-Sevilla, PCorresponding Author

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November 1, 2021
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Near infrared bioimaging and biosensing with semiconductor and rare-earth nanoparticles: recent developments in multifunctional nanomaterials

Publicated to:Nanoscale Advances. 3 (22): 6310-6329 - 2021-11-21 3(22), DOI: 10.1039/d1na00502b

Authors: Skripka, Artiom; Mendez-Gonzalez, Diego; Marin, Riccardo; Ximendes, Erving; del Rosal, Blanca; Jaque, Daniel; Rodriguez-Sevilla, Paloma;

Affiliations

Inst Ramon y Cajal Invest Sanitaria IRYCIS, Ctra Colmenar Km 9-100, Madrid 28034, Spain - Author
Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA - Author
RMIT Univ, ARC Ctr Excellence Nanoscale BioPhoton, Sch Sci, 124 La Trobe St, Melbourne, Vic 3000, Australia - Author
Univ Autonoma Madrid, Fac Ciencias, Dept Fis Mat, Nanomat Bioimaging Grp, Madrid 28049, Spain - Author

Abstract

Research in novel materials has been extremely active over the past few decades, wherein a major area of interest has been nanoparticles with special optical properties. These structures can overcome some of the intrinsic limitations of contrast agents routinely used in medical practice, while offering additional functionalities. Materials that absorb or scatter near infrared light, to which biological tissues are partially transparent, have attracted significant attention and demonstrated their potential in preclinical research. In this review, we provide an at-a-glance overview of the most recent developments in near infrared nanoparticles that could have far-reaching applications in the life sciences. We focus on materials that offer additional functionalities besides diagnosis based on optical contrast: multiple imaging modalities (multimodal imaging), sensing of physical and chemical cues (multivariate diagnosis), or therapeutic activity (theranostics). Besides presenting relevant case studies for each class of optically active materials, we discuss their design and safety considerations, detailing the potential hurdles that may complicate their clinical translation. While multifunctional nanomaterials have shown promise in preclinical research, the field is still in its infancy; there is plenty of room to maximize its impact in preclinical studies as well as to deliver it to the clinics.

Keywords

DesignEmissionGraphene quantum dotsHighly efficientLightLuminescenceNanocrystalsPerovskiteShellUp-conversion nanoparticles

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nanoscale Advances due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Engineering (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.48. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.06 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 4.31 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 20
  • Scopus: 29
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 29.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 29 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.3.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Australia; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SKRIPKA, ARTIOM) and Last Author (RODRIGUEZ SEVILLA, PALOMA).

the authors responsible for correspondence tasks have been JAQUE GARCIA, DANIEL and RODRIGUEZ SEVILLA, PALOMA.