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Analysis of institutional authors

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Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Qpool

Publicated to:Science Advances. 6 (26): eaba7509- - 2020-06-01 6(26), DOI: 10.1126/sciadv.aba7509

Authors: Calvo E; Cogliati S; Hernansanz-Agustín P; Loureiro-López M; Guarás A; Casuso RA; García-Marqués F; Acín-Pérez R; Martí-Mateos Y; Silla-Castro JC; Carro-Alvarellos M; Huertas JR; Vázquez J; Enríquez JA

Affiliations

Centro Nacional de Investigaciones Cardiovasculares Carlos III - Author
CIBERCV - Author
CiberCV, Madrid, Spain - Author
CIBERFES - Author
CIBERFES, Madrid, Spain - Author
Ctr Nacl Invest Cardiovasc Carlos III, Madrid 28029, Spain - Author
Univ Granada, Biomed Res Ctr, Dept Physiol, Inst Nutr & Food Technol, Granada, Spain - Author
Univ Southern Denmark, Dept Biochem & Mol Biol, Campusvej 55, DK-5230 Odense, Denmark - Author
Universidad de Granada - Author
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Abstract

Mitochondrial respiratory complexes assemble into supercomplexes (SC). Q-respirasome (III2 + IV) requires the supercomplex assembly factor (SCAF1) protein. The role of this factor in the N-respirasome (I + III2 + IV) and the physiological role of SCs are controversial. Here, we study C57BL/6J mice harboring nonfunctional SCAF1, the full knockout for SCAF1, or the wild-type version of the protein and found that exercise performance is SCAF1 dependent. By combining quantitative data–independent proteomics, 2D Blue native gel electrophoresis, and functional analysis of enriched respirasome fractions, we show that SCAF1 confers structural attachment between III2 and IV within the N-respirasome, increases NADH-dependent respiration, and reduces reactive oxygen species (ROS). Furthermore, the expression of AOX in cells and mice confirms that CI-CIII superassembly segments the CoQ in two pools and modulates CI-NADH oxidative capacity.

Keywords
architecturechaincomplex-icox7a2lelectron-transportexercisekinetic evidencemitochondriaorganizationCytochrome-c-oxidase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Science Advances due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 5/73, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.35. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.23 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 11.44 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-11, the following number of citations:

  • WoS: 55
  • Scopus: 75
  • Europe PMC: 39
  • OpenCitations: 76
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-11:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 102.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 102 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 23.4.
  • The number of mentions on the social network X (formerly Twitter): 38 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Denmark.