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Citations

298

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Grant support

The authors thank M. N. Navarro and G. Soto-Heredero for helpful comments on the manuscript. This study was supported by the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI19/855), the European Regional Development Fund (ERDF) and the European Commission through H2020-EU.1.1, European Research Council grant ERC-2016-StG 715322-EndoMitTalk and the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with Universidad Autonoma de Madrid in the line of action encouraging youth research doctors, in the context of the V PRICIT (Regional Programme of Research and Technological Innovation) (SI1/PJI/2019-00073). M.M. is supported by the Miguel Servet Program (CP 19/014, Fundacion de Investigacion del Hospital 12 de Octubre). M.M.G.H. and E.G.-R. are supported by an FPU grant (FPU19/02576) and a Juan de la Cierva grant (IJC2018-036850-I), respectively, both from Ministerio de Ciencia, Innovacion y Universidades (Spain).

Analysis of institutional authors

Montero Gomez De Las Heras, ManuelAuthorCarrasco, EAuthorGabande-Rodriguez, EAuthorAranda, JfAuthorMittelbrunn, MCorresponding Author
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Review

The role of T cells in age-related diseases

Publicated to:NATURE REVIEWS IMMUNOLOGY. 22 (2): 97-111 - 2022-02-01 22(2), DOI: 10.1038/s41577-021-00557-4

Authors: Carrasco, Elisa; Gomez de las Heras, Manuel M; Gabande-Rodriguez, Enrique; Desdin-Mico, Gabriela; Francisco Aranda, Juan; Mittelbrunn, Maria

Affiliations

‎ Inst Invest Sanitaria Hosp 12 Octubre i 12, Madrid, Spain - Author
‎ Univ Autonoma Madrid, Ctr Biol Mol Severe Ochoa CSIC UAM, Madrid, Spain - Author
‎ Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol Mol, Madrid, Spain - Author
‎ Univ Autonoma Madrid, Fac Ciencias UAM, Dept Biol, Madrid, Spain - Author

Abstract

In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases. Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that 'resetting' immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.

Keywords
Abdominal aortic-aneurysmAdaptive immunityAgingAtherosclerotic plaquesCentral-nervous-systemCytokinesDiet-induced obesityGastrointestinal microbiomeGut microbiotaHumansIfn-gammaImmune toleranceInsulin-resistanceInterferon-gammaT-lymphocytesVisceral adipose-tissue

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NATURE REVIEWS IMMUNOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 1/161, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 21.53. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 17.58 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 25.13 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-13, the following number of citations:

  • WoS: 107
  • Scopus: 116
  • Europe PMC: 75
  • OpenCitations: 105
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 260.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 258 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 73.98.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 122 (Altmetric).
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CARRASCO CERRO, ELISA) and Last Author (MITTELBRUNN HERRERO, MARIA).

the author responsible for correspondence tasks has been MITTELBRUNN HERRERO, MARIA.