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Analysis of institutional authors

Alonso De Leciñana MAuthorRodríguez-Yañez MAuthorDíez Sebastián JAuthorLisbona AAuthorDiez-Tejedor EAuthorFuentes BCorresponding Author

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April 16, 2021
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Article

Beyond hyperglycemia: glycaemic variability as a prognostic factor after acute ischemic stroke

Publicated to:NEUROLOGIA. 38 (3): 150-158 - 2023-04-01 38(3), DOI: 10.1016/j.nrl.2020.06.018

Authors: Gutiérrez-Zúñiga R, Alonso de Leciñana M, Delgado-Mederos R, Gállego-Cullere J, Rodríguez-Yáñez M, Martínez-Zabaleta M, Freijo M, Portilla JC, Gil-Núñez A, Díez Sebastián J, Lisbona A, Díez-Tejedor E, Fuentes B, Proyecto Ictus del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología, RETICS INVICTUS e INVICTUS Plus

Affiliations

Complejo Hosp Navarra, Serv Neurol, Pamplona, Spain - Author
Hosp Clin Univ, Serv Neurol, Santiago De Compostela, Spain - Author
Hosp San Pedro Alcantara, Serv Neurol, Caceres, Spain - Author
Hosp Santa Creu & Sant Pau, Serv Neurol, Barcelona, Spain - Author
Hosp Univ Donostia, Serv Neurol, San Sebastian, Spain - Author
Hosp Univ Gregorio Maranon, Serv Neurol, Madrid, Spain - Author
IIS Biocruces Bizkaia, Serv Neurol, Bilbao, Spain - Author
NULL - Author
Servicio de Bioestadística, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, España. - Author
Servicio de Endocrinología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, España. - Author
Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, España. - Author
Servicio de Neurología, Hospital Clínico Universitario, Santiago de Compostela, España. - Author
Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Barcelona, España. - Author
Servicio de Neurología, Hospital San Pedro de Alcántara, Cáceres, España. - Author
Servicio de Neurología, Hospital Universitario Donostia, San Sebastián, España. - Author
Servicio de Neurología, Hospital Universitario Gregorio Marañón, Madrid, España. - Author
Servicio de Neurología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, España. - Author
Servicio de Neurología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, España. Electronic address: blanca.fuentes@salud.madrid.org. - Author
Servicio de Neurología, IIS Biocruces-Bizkaia, Bilbao, España. - Author
Univ Autonoma Madrid, Hosp Univ La Paz, Serv Bioestadist, Madrid, Spain - Author
Univ Autonoma Madrid, Hosp Univ La Paz, Serv Endocrinol, Madrid, Spain - Author
Univ Autonoma Madrid, Hosp Univ La Paz, Serv Neurol, Madrid, Spain - Author
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Abstract

Glycaemic variability (GV) refers to variations in blood glucose levels, and may affect stroke outcomes. This study aims to assess the effect of GV on acute ischaemic stroke progression.We performed an exploratory analysis of the multicentre, prospective, observational GLIAS-II study. Capillary glucose levels were measured every 4 hours during the first 48 hours after stroke, and GV was defined as the standard deviation of the mean glucose values. The primary outcomes were mortality and death or dependency at 3 months. Secondary outcomes were in-hospital complications, stroke recurrence, and the impact of the route of insulin administration on GV.A total of 213 patients were included. Higher GV values were observed in patients who died (n = 16; 7.8%; 30.9 mg/dL vs 23.3 mg/dL; p = 0.05). In a logistic regression analysis adjusted for age and comorbidity, both GV (OR = 1.03; 95% CI, 1.003-1.06; p = 0.03) and stroke severity (OR = 1.12; 95% CI, 1.04-1.2; p = 0.004) were independently associated with mortality at 3 months. No association was found between GV and the other outcomes. Patients receiving subcutaneous insulin showed higher GV than those treated with intravenous insulin (38.95 mg/dL vs 21.34 mg/dL; p < 0.001).High GV values during the first 48 hours after ischaemic stroke were independently associated with mortality. Subcutaneous insulin may be associated with higher VG levels than intravenous administration.Copyright © 2020 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Keywords

glucose variabilityglycaemic variabilityinsulinmortalityoutcomespost-stroke hyperglycaemiaGlycaemic variabilityHiperglucemia postictusInfarto cerebralInsulinInsulinaIschemic strokeOutcomesPost-stroke hyperglycaemiaPoststroke hyperglycemiaPronósticoVariabilidad glucémica

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NEUROLOGIA due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 102/280, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Clinical Neurology. Notably, the journal is positioned en el Cuartil Q3 para la agencia Scopus (SJR) en la categoría Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.69, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-06, the following number of citations:

  • WoS: 2
  • Scopus: 8
  • Europe PMC: 1
  • Google Scholar: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 25 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Additionally, the work has been submitted to a journal classified as Diamond in relation to this type of editorial policy.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/708957

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Gutiérrez-Zúñiga R) .

the author responsible for correspondence tasks has been FUENTES GIMENO, BLANCA EULALIA.