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Analysis of institutional authors

Mora-Guzmán IAuthorMartín-Pérez EAuthor

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April 15, 2021
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Infecciones asociadas a enterobacterias productoras de carbapenemasas OXA-48 en pacientes quirúrgicos: consumo de antibióticos y evolución de sensibilidades

Publicated to:Revista Espanola de Quimioterapia. 33 (6): 448-452 - 2020-01-01 33(6), DOI: 10.37201/req/081.2020

Authors: Mora-Guzmán I; Rubio-Pérez I; Domingo-Garcia D; Martín-Pérez E

Affiliations

Hospital General La Mancha Centro - Author
Hospital Universitario de la Princesa - Author
Hospital Universitario La Paz - Author

Abstract

Objective. To assess antibiotic consumption, susceptibility patterns and targeted treatment for OXA-48 carbapene-mase-producing Enterobacteriaceae (CPE) related infections in surgical patients in a General Surgery Department. Material and methods. Retrospective review of patients with a positive culture for OXA-48 and associated clinical data of infection, while hospitalized in a General Surgery Department from January 2013 to December 2018. Results. Sixty-five patients with 66 isolations (OXA-48) were included: Klebsiella pneumoniae, 57 (86.5%); Enterobac-ter cloacae, 5 (7.6%); Escherichia coli, 3 (4.5%); Morganella morganii, 1 (1.5%). The most frequent source was intra-ab-dominal infection (n=39, 60%), and previous antibiotic consumption was: piperacillin-tazobactam (48%), meropenem (45%), ciprofloxacin (25.5%), ertapenem (16.5%), imipenem (12%), amikacin (12%), tigecycline (12%). Temporal trends (2013/14, 2015/16 and 2017/18) in susceptibility patterns were (percentages): ceftazidime-avibactam X-X-100; amikacin 100-96-84 (p=0.518); tigecycline 100-92-80 (p=0.437); colistin 100-67-66 (p<0.001); meropenem 37-64-72 (p=0.214); imi-penem 51-41-77 (p=0.109); gentamicin 13-19-18 (p=0.879); ertapenem 35-0-0 (p<0.001). Median duration of the targeted antibiotic therapy was 14 [IQR 9-20] days; antibiotics used were: tigecycline (57%); meropenem (40.5%); amikacin (37.5%); ceftazidime-avibactam (9%); imipenem (7.5%); colis-tin (7.5%). Global mortality rate at 30 days was 12% (8 pa-tients). Targeted treatment was appropriate (antibiogram) in 87.7%, and targeted combination scheme was administered in 76.9%, which included a carbapenem in 49.2%. Conclusions. OXA-48-related-intra-abdominal infection is significant in surgical patients, with substantial broad-spec-trum antibiotic consumption. Useful targeted therapy includes ceftazidime-avibactam, amikacin, tigecycline, meropenem, and imipenem.

Keywords

carbapenemaseenterobacteriaceaeCarbapenemaseEnterobacteriaceaeResistance

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Revista Espanola de Quimioterapia, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Microbiology, give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-18:

  • WoS: 4
  • Scopus: 3
  • Europe PMC: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 45 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Additionally, the work has been submitted to a journal classified as Diamond in relation to this type of editorial policy.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (RUBIO PEREZ, INES) and Last Author (MARTIN PEREZ, MARIA ELENA).