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Analysis of institutional authors

García-Moreno MAuthor

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October 19, 2020
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The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity

Publicated to:SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 111 108-118 - 2021-03-01 111(), DOI: 10.1016/j.semcdb.2020.08.002

Authors: Dicker K; Järvelin AI; Garcia-Moreno M; Castello A

Affiliations

MRC-University of Glasgow Centre for Virus Research - Author
University of Oxford - Author

Abstract

© 2020 Elsevier Ltd RNA is a central molecule in RNA virus biology due to its dual function as messenger and genome. However, the small number of proteins encoded by viral genomes is insufficient to enable virus infection. Hence, viruses hijack cellular RNA-binding proteins (RBPs) to aid replication and spread. In this review we discuss the ‘knowns’ and ‘unknowns’ regarding the contribution of host RBPs to the formation of viral particles and the initial steps of infection in the newly infected cell. Through comparison of the virion proteomes of ten different human RNA viruses, we confirm that a pool of cellular RBPs are typically incorporated into viral particles. We describe here illustrative examples supporting the important functions of these RBPs in viral particle formation and infectivity and we propose that the role of host RBPs in these steps can be broader than previously anticipated. Understanding how cellular RBPs regulate virus infection can lead to the discovery of novel therapeutic targets against viruses.

Keywords

protein-rna interactionrbprna-binding proteinvirusvirus assemblyvirus infectionProtein-rna interactionRbpRna-binding proteinVirusVirus assemblyVirus infectionVirus replication

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 4/39, thus managing to position itself as a Q1 (Primer Cuartil), in the category Developmental Biology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.02, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-03, the following number of citations:

  • WoS: 7
  • Scopus: 8

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-03:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 64 (PlumX).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.