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Analysis of institutional authors

Soto-Heredero GAuthorMittelbrunn MCorresponding Author
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Mitochondrial activity in T cells

Publicated to:MITOCHONDRION. 41 51-57 - 2018-07-01 41(), DOI: 10.1016/j.mito.2017.10.006

Authors: Desdin-Mico, Gabriela; Soto-Heredero, Gonzalo; Mittelbrunn, Maria

Affiliations

CSIC UAM, Ctr Biol Mol Severo Ochoa, Nicolas Cabrera 1, Madrid 28049, Spain - Author
CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM) - Author
Hosp Univ 12 Octubre I 12, Inst Invest, Ave Cordoba S-N, Madrid 28041, Spain - Author
Hospital Universitario 12 de octubre - Author

Abstract

© 2018 The Authors Mitochondria fulfill important and diverse roles during the different stages of T cell adaptive responses. Here we discuss the role of the mitochondria in T cells from the initial steps of activation at the immune synapse to their participation in memory response and T cell exhaustion. Mitochondria are relocated to the immune synapse in order to supply local ATP and to aid calcium signaling. During expansion and proliferation, mitochondrial reactive oxygen species drive proliferation. Aerobic glycolysis, glutaminolysis and fatty acid oxidation regulate the program of differentiation into effector or regulatory T cell subsets, and mitochondrial remodeling proteins are required for the long-lasting phenotype of memory cells.

Keywords
calcium signalingimmune synapseimmunometabolismimmunotherapyinflammationmitochondrial rosActivationAnimalsBiogenesisC-mycCa2+ microdomainsCalcium signalingDifferentiationEffectorEnergy metabolismHumansImmune synapseImmunity, innateImmunometabolismImmunotherapyInflammationMemoryMetabolic checkpointMetabolic diseasesMitochondriaMitochondrial rosMolecular-mechanismsOrganelle communicationPlasticitySignal transductionT-lymphocytes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MITOCHONDRION due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Molecular Medicine.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.79 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 12.69 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-13, the following number of citations:

  • WoS: 110
  • Scopus: 119
  • Europe PMC: 89
  • OpenCitations: 120
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 257.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 257 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 29.7.
  • The number of mentions on the social network X (formerly Twitter): 61 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Desdín-Micó G) and Last Author (MITTELBRUNN HERRERO, MARIA).

the author responsible for correspondence tasks has been MITTELBRUNN HERRERO, MARIA.