{rfName}
Fu

Indexed in

License and use

Citations

186

Altmetrics

Analysis of institutional authors

Sanchez Madrid, FranciscoAuthorLamana AAuthorDe La Fuente HAuthorOlazabal IAuthor

Share

October 19, 2020
Publications
>
Article
Bronze

Functional role of P-selectin glycoprotein ligand 1/P-selectin interaction in the generation of tolerogenic dendritic cells

Publicated to:JOURNAL OF IMMUNOLOGY. 179 (11): 7457-7465 - 2007-12-01 179(11), DOI: 10.4049/jimmunol.179.11.7457

Authors: Urzainqui, Ana; Martinez del Hoyo, Gloria; Lamana, Amalia; de la Fuente, Hortensia; Barreiro, Olga; Olazabal, Isabel M; Martin, Pilar; Wild, Martin K; Vestweber, Dietmar; Gonzalez-Amaro, Roberto; Sanchez-Madrid, Francisco

Affiliations

- Author
Centro Nacional de Investigaciones Cardiovasculares Carlos III - Author
Hospital Universitario de la Princesa - Author
Max Planck Institute for Molecular Biomedicine - Author
Universidad Autonoma de San Luis Potosi, Facultad de Medicina - Author
See more

Abstract

Dendritic cells (DCs) have a key role in both the generation of the immune response and the induction of tolerance to self-Ags. In this work, the possible role of P-selectin glycoprotein ligand 1 (PSGL-1) on the tolerogenic activity of human DCs was explored. We found that the engagement of PSGL-1 by P-selectin on DCs induced the expression of c-Fos, IDO, IL-10, and TGF-β genes. Remarkably, stimulation of DCs through PSGL-1 with P-selectin enhanced their capability to generate CD4+CD25+Foxp3+ regulatory T cells, which expressed high levels of TGF-β1 mRNA, synthesized IL-10, and suppressed the proliferation of autologous CD4+CD25 - T cells. Accordingly, we found that DCs from PSGL-1-/- mice expressed higher levels of MHC class II molecules, and exhibited an enhanced immunogenicity compared with wild-type mice. In addition, the percentage of CD4+CD25+Foxp3+ regulatory T cells in the thymus of PSGL-1-deficient animals was significantly reduced. Our data reveal an unexpected role of PSGL-1 on the tolerogenic function of DCs, and the regulation of the immune response. Copyright © 2007 by The American Association of Immunologists, Inc.

Keywords

Astronomia / físicaBiodiversidadeBiotecnologíaCiências biológicas iCiências biológicas iiCiências biológicas iiiEconomiaEducação físicaEngenharias iiEngenharias ivFarmaciaGeneral medicineImmunologyImmunology and allergyInterdisciplinarMedicina iMedicina iiMedicina iiiNutriçãoOdontologíaSaúde coletiva

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF IMMUNOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2007, it was in position 13/119, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 8.65, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-09, the following number of citations:

  • WoS: 75
  • Scopus: 79
  • Europe PMC: 30

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 47.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 47 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Urzainqui A) and Last Author (Sanchez-Madrid F).

the author responsible for correspondence tasks has been Sanchez-Madrid F.