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Analysis of institutional authors

Mayor Menendez, FedericoAuthorPenela Marquez, PetronilaAuthorMurga Montesinos, CristinaAuthorRibas CAuthorSalcedo ACorresponding Author

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October 19, 2020
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The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling

Publicated to:BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1768 (4): 913-922 - 2007-04-01 1768(4), DOI: 10.1016/j.bbamem.2006.09.019

Authors: Ribas C; Penela P; Murga C; Salcedo A; García-Hoz C; Jurado-Pueyo M; Aymerich I; Mayor F

Affiliations

Consejo Superior de Investigaciones Científicas - Author

Abstract

G protein-coupled receptor kinases (GRKs) and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent GPCR desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellular signaling cascades by GPCR. Novel studies have revealed a phosphorylation-independent desensitization mechanism operating through their RGS-homology (RH) domain and the recent determination of the crystal structures of GRK2 and GRK6 has uncovered interesting details on the structure-function relationships of these kinases. Emerging evidence indicates that the activity of GRKs is tightly modulated by mechanisms including phosphorylation by different kinases and interaction with several cellular proteins such as calmodulin, caveolin or RKIP. In addition, GRKs are involved in multiple interactions with non-receptor proteins (PI3K, Akt, GIT or MEK) that point to novel GRK cellular roles. In this article, our purpose is to describe the ever increasing map of functional interactions for GRK proteins as a basis to better understand its contribution to cellular processes. © 2006 Elsevier B.V. All rights reserved.

Keywords

ArrestinG proteinGpcrGrksKinase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2007, it was in position 15/69, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biophysics.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 22.36, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 303
  • Scopus: 330
  • Europe PMC: 189

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 388.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 391 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on Wikipedia: 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (RIBAS NUÑEZ, CATALINA) .

the author responsible for correspondence tasks has been SALCEDO DE HARO, ALICIA.