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Analysis of institutional authors

Gonzalez Baron, ManuelAuthorRodriguez Salas, NuriaAuthorMoreno GAuthorGamallo Amat, CarlosAuthor

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October 19, 2020
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Beta-catenin expression pattern in small cell lung cancer: correlation with clinical and evolutive features

Publicated to:Histology And Histopathology: Cellular And Molecular Biology. 16 (2): 353-358 - 2001-04-25 16(2), DOI: 10.14670/HH-16.353

Authors: Rodríguez-Salas, N; Palacios, J; de Castro, J; Moreno, G; González-Barón, M; Gamallo, C

Affiliations

- Author
Hospital Universitario de la Princesa - Author

Abstract

β-Catenin expression in small cell lung carcinomas (SCLC) was investigated by immunohistochemical method using antibodies against β-catenin. 50 pre-treatment biopsies were examined and the relationship between β-catenin expression and the patients' relevant clinical characteristics, response to chemotherapy, time to relapse or progression, and overall survival, were analyzed. β-Catenin expression exhibited different intensity within each sample, predominantly localized in the cytoplasm, and no sample showed nuclear expression. There was cytoplasmic hyperexpression in 14 cases, hypoexpression in 15 cases, and normal expression in 21 cases. We did not find any association between β-catenin expression and clinical data. Our results show, however, correlation between β-Catenin cytoplasmic hyperexpression with a shorter time to progression (p=0.0437) as well as with a shorter overall survival (p=0.0253). β-catenin hyperexpression could have prognostic significance in SCLC.

Keywords

ImmunohistochemistryOverall survivalSmall cell lung cancerTime to progressionΒ-catenin

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Histology And Histopathology: Cellular And Molecular Biology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2001, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pathology and Forensic Medicine.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.06, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 20
  • Scopus: 19
  • Europe PMC: 14

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (RODRIGUEZ SALAS, NURIA) and Last Author (GAMALLO AMAT, CARLOS).