{rfName}
Hi

Indexed in

License and Use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Gil-Ramirez, AliciaAuthorArranz EAuthorRuiz-Rodriguez, AlejandroAuthorReglero, GuillermoAuthorMarin, Francisco RCorresponding Author

Share

September 14, 2020
Publications
>
Article

Highly isoxanthohumol enriched hop extract obtained by pressurized hot water extraction (PHWE). Chemical and functional characterization

Publicated to: Innovative Food Science & Emerging Technologies. 16 54-60 - 2012-10-01 16(), DOI: 10.1016/j.ifset.2012.04.006

Authors:

Gil-Ramírez, A; Mendiola, JA; Arranz, E; Ruíz-Rodríguez, A; Reglero, G; Ibáñez, E; Marín, FR
[+]

Affiliations

Consejo Superior de Investigaciones Científicas - Author
Univ Autonoma Madrid, Dept Bioact & Food Anal, Inst Food Sci Res CIAL, Spanish Natl Res Council, E-28049 Madrid, Spain - Author
Univ Autonoma Madrid, Dept Characterizat & Prod New Foods, Inst Food Sci Res CIAL, Spanish Natl Res Council, E-28049 Madrid, Spain - Author
Universidad Autónoma de Madrid - Author
See more

Abstract

Hop (Humulus lupulus) is one of the richest natural sources of a prenylfalvonoids such as xanthohumol (XN), desmetylxanthohumol (DMX), isoxanthohumol (IX) or 8-prenylnaringenin (8-PN), being XN the most abundant of them in the raw material. So far, obtention of prenylflavonoids has been done by chemical synthesis or extraction with organic solvents, with no described methods for the isolation of IX, which has been reported to have anti-inflammatory properties. In this study, pressurized hot water extraction (PHWE) is shown not only as an effective method to extract some prenylflavonoids but also to selectively change the relative amount of them, favoring the extraction of IX against XN. Thus, pressurized water extraction at 150°C showed a high selectivity towards IX, being proposed as a method to enrich natural hop's extracts in IX. On the other hand, the extracts thus obtained were chemically characterized and evaluated for their anti-inflammatory activity, which was higher than the expected by its content in IX. Industrial relevance: One of the few commercial segments of the food industry with growing potential is functional foods. In this paper we present an environmentally friendly method to obtain hop extracts with anti-inflammatory properties. We are applied for a national (Spanish) patent (application number: P-201131014) to protect a method to produce an anti-inflammatory beverage. Inflammation underlies a bunch of pathologies and altered physiological status such as obesity, atherosclerosis, etc. Other potential use of the process, and the product, is to be the first step in the production of pernylnaringenin, which is the strongest phytoestrogen ever known, over 1000 times more potent than soy isoflavones, and with a putative medical use. Notwithstanding, further steps such as anaerobic fermentation to selectively methylate the isoxanthohumol are needed. © 2012 Elsevier Ltd.
[+]

Keywords

Anti-inflammatoryIsoxanthohumol (ix)PrenylflavonoidsPressurized hot water extraction (phwe)Xanthohumol (xn)

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Innovative Food Science & Emerging Technologies due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 23/124, thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science & Technology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.53. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.44 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-02-08, the following number of citations:

  • WoS: 35
  • Scopus: 35
  • Europe PMC: 2
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-02-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 69.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 69 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
[+]

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (GIL RAMIREZ, ALICIA) and Last Author (MARIN MARTIN, FRANCISCO RAMON).

the author responsible for correspondence tasks has been MARIN MARTIN, FRANCISCO RAMON.

[+]