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Grant support

We thank Dr E. Carrasco for helpful ideas and comments on the manuscript. This work was supported by the H2020-EU.1.1, European Research Council (ERC-2016-StG 715322-EndoMitTalk), and Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI16/188, PI19/855), Fondo Europeo de Desarrollo Regional (FEDER). GS-H was funded by a FPI-UAM grant (Universidad Autonoma de Madrid). MMGH was funded by ERC. EG-R was funded by a Juan de la Cierva grant (IJC2018-036850-I; Universidad Autonoma de Madrid). JO was funded by a Juan de la Cierva grant (FJCI-2017-33855; Universidad Autonoma de Madrid). M.M. was supported by the Miguel Servet programme from the Instituto de Salud Carlos III (Fundacion de Investigacion del Hospital 12 de Octubre).

Analysis of institutional authors

Montero Gomez De Las Heras, ManuelAuthorSoto-Heredero, GonzaloCorresponding AuthorGabande-Rodriguez, EnriqueAuthorOller, JorgeAuthorMittelbrunn, MariaCorresponding Author
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Review

Glycolysis - a key player in the inflammatory response

Publicated to:FEBS Journal. 287 (16): 3350-3369 - 2020-08-01 287(16), DOI: 10.1111/febs.15327

Authors: Soto-Heredero, Gonzalo; Gomez de las Heras, Manuel M; Gabande-Rodriguez, Enrique; Oller, Jorge; Mittelbrunn, Maria

Affiliations

Ctr Biol Mol Severo Ochoa, Cellular Commun & Inflammat Unit, Immunometab & Inflammat Lab, Madrid, Spain - Author
Inst Invest Sanitaria Hosp 12 Octubre imas12, Madrid, Spain - Author
UAM, Fac Sci, Dept Mol Biol, Madrid, Spain - Author

Abstract

The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lymphocytes or activated microglia, must rapidly provide energy to fuel inflammation, which is essentially accomplished by glycolysis and high lactate production. On the other hand, regulatory T cells or M2 macrophages, which are involved in immune regulation and resolution of inflammation, preferentially use fatty acid oxidation through the TCA cycle as a main source for energy production. Here, we discuss the impact of glycolytic metabolism at the different steps of the inflammatory response. Finally, we review a wide variety of molecular mechanisms which could explain the relationship between glycolytic metabolites and the pro-inflammatory phenotype, including signalling events, epigenetic remodelling, post-transcriptional regulation and post-translational modifications. Inflammatory processes are a common feature of many age-associated diseases, such as cardiovascular and neurodegenerative disorders. The finding that immunometabolism could be a master regulator of inflammation broadens the avenue for treating inflammation-related pathologies through the manipulation of the vascular and immune cell metabolism.

Keywords
ageingimmune cellsimmunometabolisminflammationAgeingAnimalsCitric acid cycleGlycolysisHumansImmune cellsImmunometabolismInflammationMacrophage activationMacrophagesMetabolitesNeurodegenerative diseasesT-lymphocytes, helper-inducerT-lymphocytes, regulatory

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal FEBS Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 72/295, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

This publication has been distinguished as a “Highly Cited Paper” by the agencies WoS (ESI, Clarivate) and ESI (Clarivate), meaning that it ranks within the top 1% of the most cited articles in its thematic field during the year of its publication. In terms of the observed impact of the contribution, this work is considered one of the most influential worldwide, as it is recognized as highly cited. (source consulted: ESI Nov 14, 2024)

And this is evidenced by the extremely high normalized impacts through some of the main indicators of this type, which, although dynamic over time and dependent on the set of average global citations at the time of calculation, already indicate that they are well above the average in different agencies:

  • Normalization of citations relative to the expected citation rate (ESI) by the Clarivate agency: 16 (source consulted: ESI Nov 14, 2024)
  • Weighted Average of Normalized Impact by the Scopus agency: 19.6 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 63.17 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-13, the following number of citations:

  • WoS: 302
  • Scopus: 345
  • Europe PMC: 212
  • OpenCitations: 319
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 402.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 400 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 44.43.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 62 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SOTO HEREDERO, GONZALO) and Last Author (MITTELBRUNN HERRERO, MARIA).

the authors responsible for correspondence tasks have been SOTO HEREDERO, GONZALO and MITTELBRUNN HERRERO, MARIA.