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Grant support

This research was funded by the H2020-EU.1.1. European Research Council (ERC-2016-StG 715322-EndoMitTalk), and Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI16/188, PI19/855), Fondo Europeo de Desarrollo Regional (FEDER). M.M. is supported by the Miguel Servet program from Instituto de Salud Carlos III (CPII19/00014, Instituto de Investigacion del Hospital 12 de Octubre).

Analysis of institutional authors

Montero Gomez De Las Heras, ManuelAuthorGabande-Rodriguez, EnriqueCorresponding AuthorMittelbrunn, MCorresponding Author

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March 16, 2020
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Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria

Publicated to:Cells. 9 (1): 82- - 2020-01-01 9(1), DOI: 10.3390/cells9010082

Authors: Gabande-Rodriguez, Enrique; Gomez de las Heras, Manuel M; Mittelbrunn, Maria

Affiliations

Hosp 12 Octubre, Inst Invest, Regulat Cellular Homeostasis Lab, Area Rare & Genet Based Dis, E-28041 Madrid, Spain - Author
Univ Autonoma Madrid, CSIC, Immunometab & Inflammat Lab,CBMSO, Tissue & Organ Homeostasis Program,Cell Cell Comm, E-28049 Madrid, Spain - Author
Univ Autonoma Madrid, Fac Sci, Dept Mol Biol, E-28049 Madrid, Spain - Author

Abstract

Mitochondrial metabolism and autophagy are two of the most metabolically active cellular processes, playing a crucial role in regulating organism longevity. In fact, both mitochondrial dysfunction or autophagy decline compromise cellular homeostasis and induce inflammation. Calorie restriction (CR) is the oldest strategy known to promote healthspan, and a plethora of CR mimetics have been used to emulate its beneficial effects. Herein, we discuss how CR and CR mimetics, by modulating mitochondrial metabolism or autophagic flux, prevent inflammatory processes, protect the intestinal barrier function, and dampen both inflammaging and neuroinflammation. We outline the effects of some compounds classically known as modulators of autophagy and mitochondrial function, such as NAD(+) precursors, metformin, spermidine, rapamycin, and resveratrol, on the control of the inflammatory cascade and how these anti-inflammatory properties could be involved in their ability to increase resilience to age-associated diseases.

Keywords

agingautophagycalorie restrictioninflammationmetabolismAgingAmyloid-betaAnimalsAnti-inflammatory agentsAutophagyBiomimeticsCaloric restrictionCalorie restrictionCentral-nervous-systemDisease susceptibilityEnergy metabolismExperimental autoimmune encephalomyelitisHomeostasisHumansInflammationLife-span extensionMetabolismMitochondriaMouse modelNf-kappa-bNicotinamide mononucleotideOxidative stressSmall-molecule activatorsTranscription factors

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cells due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.58. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.86 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 9.09 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-18, the following number of citations:

  • WoS: 62
  • Scopus: 67
  • Europe PMC: 39

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 129.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 137 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 29.15.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 32 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/691264

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (GABANDE RODRIGUEZ, ENRIQUE) and Last Author (MITTELBRUNN HERRERO, MARIA).

the authors responsible for correspondence tasks have been GABANDE RODRIGUEZ, ENRIQUE and MITTELBRUNN HERRERO, MARIA.