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Analysis of institutional authors

Calles-Sastre LAuthorSan-Frutos Llorente LmAuthorGarcía-Espantaleón Navas MAuthorPerez-Medina TAuthor
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Significación pronóstica del volumen metabólico tumoral y de la glucólisis tumoral total en pacientes con cáncer cervical avanzado

Publicated to:Revista Espanola de Medicina Nuclear e Imagen Molecular. 38 (1): 17-21 - 2019-01-01 38(1), DOI: 10.1016/j.remn.2018.08.001

Authors: Calles Sastre, Laura; Mucientes Rasilla, Jorge; San Frutos Llorente, Luis; Royuela Vicente, Ana; García-Espantaleón Navas, Manuel; Herrero, S; Pérez Medina, Tirso

Affiliations

Department of Biostatistical Unit, Autonoma University of Madrid, Puerta de Hierro University Hospital, Spain - Author
Department of Nuclear Medicine, Autonoma University of Madrid, Puerta de Hierro University Hospital, Spain - Author
Department of Obstetrics and Gynecology, Autonoma University of Madrid, Puerta de Hierro University Hospital, Spain - Author

Abstract

18-Fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG PET/CT) is considered to be the most accurate image method of detection of node or distant metastases in cervical cancer. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of 18F-FDG PET/CT are volumetric measurements of tumor cells with increased 18F-FDG uptake. The prognostic value of MTV and TLG in patients with advanced cervical cancer (ACC) were evaluated.38 patients with ACC from one tertiary university hospital underwent 18F-FDG PET/CT between June 2009 and December 2015. Clinicopathologic factors and various PET parameters were analyzed to evaluate their relationship with recurrence-free survival (RFS) and overall survival (OS). These parameters were: maximum standardized uptake value (SUVmax), mean standardized uptake value (SUV mean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumor, of the pelvic nodes, of the paraaortic nodes and the metabolic volume of the metastases if any.A total of 38 patients with ACC fulfilled the inclusion criteria. All of them underwent a 18F-FDG PET/CT before definitive chemoradiotherapy. In the univariate analyses higher tumor size, pelvic lymph node metastasis and both MTV and TLG showed a significant association with OS and with RFS (MTV HR=1.55, p=0.011 and TLG HR=1.43, p=0.017 for RFS and MTV HR=1.82, p=0.006 and TLG HR=1.67, p=0.007 for OS).Pretreatment TLG sum and MTV sum seem to be independent prognostic factors for OS and RFS in patients with advanced cervical cancer treated with definitive chemoradiotherapy and they are better than the classic measurement of SUVmax.Copyright © 2018 Sociedad Española de Medicina Nuclear e Imagen Molecular. Publicado por Elsevier España, S.L.U. All rights reserved.

Keywords
Cáncer cervicalCervical cancerGlucólisis tumoral totalMetabolic tumor volumePet/ctPet/tcPrognosticProgresionPronósticoRecurrenceTotal lesion glycolysisVolumen metabólico tumoral

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Revista Espanola de Medicina Nuclear e Imagen Molecular, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Radiology, Nuclear Medicine & Medical Imaging, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.37, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-22, the following number of citations:

  • WoS: 5
  • Scopus: 10
  • Europe PMC: 3
  • OpenCitations: 2
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-22:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CALLES SASTRE, LAURA BEATRIZ) and Last Author (PEREZ MEDINA, TIRSO).