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Analysis of institutional authors

Calvo-Sánchez MAuthorCarrasco EAuthorMoreno-Bueno GAuthorEspada JAuthor

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February 26, 2019
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Hybrid Gold

A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle

Publicated to:Journal of Molecular Cell Biology. 11 (1): 39-52 - 2019-01-01 11(1), DOI: 10.1093/jmcb/mjy051

Authors: Calvo-Sanchez, Maria I; Fernandez-Martos, Sandra; Carrasco, Elisa; Moreno-Bueno, Gema; Bernabeu, Carmelo; Quintanilla, Miguel; Espada, Jesus

Affiliations

Centro de Investigacion Biomedica en Red de Cancer (CIBERONC) - Author
CSIC - Centro de Investigaciones Biologicas (CIB) - Author
CSIC, Ctr Invest Biol, E-28040 Madrid, Spain - Author
CSIC-UAM - Instituto de Investigaciones Biomédicas Alberto Sols (IIBM) - Author
Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain - Author
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid 28040, Spain - Author
Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain - Author
UFV, Fac Ciencias Expt, Inst Invest Biosanitarias, Pozuelo De Alarcon 28223, Spain - Author
Univ Autonoma Madrid, Dept Bioquim, CSIC, Inst Invest Biomed Alberto Sots, Madrid 28029, Spain - Author
Univ Bernardo OHiggins, Ctr Integrat Biol & Quim Aplicada, Santiago 8370854, Chile - Author
Universidad Bernardo O'Higgins - Author
Universidad Francisco de Vitoria - Author
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Abstract

The hair follicle is a biological oscillator that alternates growth, regression, and rest phases driven by the sequential activation of the proliferation/differentiation programs of resident stem cell populations. The activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling, while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity. A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling pathways. Here we have focused on the role of Endoglin (Eng), a key co-receptor for members of the Tgf-β/Bmp family of growth factors. Using an Eng haploinsufficient mouse model, we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell niches. We further report that β-catenin binds to the Eng promoter depending on Bmp signalling. Moreover, we show that β-catenin interacts with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter transcription. These observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals.

Keywords

ActivationBeta-cateninBmpComprehensive guideEndoglinGrowthHair follicleLabel-retaining cellsMouse skinNicheOrganizationProliferationSkin stem cellsSmadStem-cellsTgf-?/bmp/smadTgf-betaWntWnt/?-catenin

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal of Molecular Cell Biology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.69, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-06, the following number of citations:

  • WoS: 30
  • Scopus: 31
  • Europe PMC: 19

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 22.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 22 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/706131

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CALVO SANCHEZ, MARIA INMACULADA) and Last Author (ESPADA REGALADO, JESUS).