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Analysis of institutional authors

Lazaro-Carrillo AAuthorTabero AAuthorVillanueva AAuthor

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November 14, 2018
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3-Hydroxykynurenic acid: Physicochemical properties and fluorescence labeling

Publicated to: DYES AND PIGMENTS. 162 552-561 - 2019-03-01 162(), DOI: 10.1016/j.dyepig.2018.10.027

Authors:

Shmidt M; García Vior M; Ezquerra Riega S; Lázaro-Martínez J; Abasolo M; Lazaro-Carrillo A; Tabero A; Villanueva A; Moglioni A; Blanco M; Stockert J
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Affiliations

IMDEA Nanociencia - Author
Universidad Autónoma de Madrid - Author
Universidad de Buenos Aires - Author
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Abstract

© 2018 Elsevier Ltd Quinoline is one of the most important heterocyclic systems in life sciences. Some derivatives are normal metabolites, and others are used as antibacterial, antimalarial, and anticancer agents. In this work, we describe the synthesis, physicochemical properties, and fluorescence features of a new 4-quinolinone fluorophore, 3-hydroxykynurenic acid (3-HOKA). 3-HOKA was obtained by alkoxide-induced rearrangement of ethyl isatinacetate followed by acidification and then alkaline hydrolysis. The fluorescent compound was characterized by NMR, MS, IR, and UV–Vis spectra. 3-HOKA can exist under a keto-enol equilibrium, but the 4-quinolinone form is the predominant tautomer. In PBS (pH = 7.4), the anionic keto form of 3-HOKA showed a maximum absorption at 368 nm, a fluorescence peak at 474 nm, and a fluorescence quantum yield (ΦF): 0.73. 3-HOKA is photostable and is a moderately weak oxygen generator. Viability assays on HeLa cells indicated that 3-HOKA did not induce significative cytotoxic effects. Under UV excitation, a bright blue fluorescence was selectively found in a singular body within the cytoplasm, a labeling pattern that suggests the possible localization of the probe in the centriole or related structures. Therefore, this novel fluorophore represents a promising prototype compound owing to its biocompatibility and potential biological applications.
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Keywords

BiocompatibilityFluorescent labelingFluorophoreQuinolinones

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal DYES AND PIGMENTS due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 1/24, thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Science, Textiles. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-20:

  • WoS: 3
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina.

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