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Analysis of institutional authors

Yébenes LCorresponding AuthorAngulo ACorresponding AuthorZamora PCorresponding AuthorSánchez-Mendez JCorresponding AuthorEspinosa ECorresponding AuthorRedondo ACorresponding AuthorFeliu JCorresponding AuthorHardisson DCorresponding Author
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Article

Comparison of risk classification between EndoPredict and MammaPrint in ER-positive/HER2-negative primary invasive breast cancer

Publicated to:PLoS ONE. 12 (9): e0183452-e0183452 - 2017-01-01 12(9), DOI: 10.1371/journal.pone.0183452

Authors: Peláez-García A; Yébenes L; Berjón A; Angulo A; Zamora P; Sánchez-Méndez J; Espinosa E; Redondo A; Heredia-Soto V; Mendiola M; Feliú J; Hardisson D

Affiliations

Hosp Univ La Paz, Dept Obstet & Gynecol, IdiPAZ, Breast Canc Unit, Madrid, Spain - Author
Hosp Univ La Paz, Dept Pathol, IdiPAZ, Madrid, Spain - Author
Hosp Univ La Paz, IdiPAZ, Dept Med Oncol, Madrid, Spain - Author
Hosp Univ La Paz, INGEMM, IdiPAZ, Mol Pathol Diagnost Unit, Madrid, Spain - Author
Hosp Univ La Paz, Mol Pathol & Therapeut Targets Grp, IdiPAZ, Madrid, Spain - Author
Hosp Univ La Paz, Translat Oncol Grp, IdiPAZ, Madrid, Spain - Author
Hospital Universitario La Paz - Author
Instituto de Salud Carlos III - Author
Minist Econ Ind & Competitividad, Inst Salud Carlos III, Ctr Invest Biorned Red Canc CIBERONC, Madrid, Spain - Author
Myriad Genet Espana SLU, Madrid, Spain - Author
Myriad Genetics España SLU - Author
Univ Autonoma Madrid, Fac Med, Madrid, Spain - Author
Universidad Autonoma de Madrid, Facultad de Medicina - Author
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Abstract

To compare the concordance in risk classification between the EndoPredict and the MammaPrint scores obtained for the same cancer samples on 40 estrogen-receptor positive/HER2-negative breast carcinomas.Formalin-fixed, paraffin-embedded invasive breast carcinoma tissues that were previously analyzed with MammaPrint as part of routine care of the patients, and were classified as high-risk (20 patients) and low-risk (20 patients), were selected to be analyzed by the EndoPredict assay, a second generation gene expression test that combines expression of 8 genes (EP score) with two clinicopathological variables (tumor size and nodal status, EPclin score).The EP score classified 15 patients as low-risk and 25 patients as high-risk. EPclin re-classified 5 of the 25 EP high-risk patients into low-risk, resulting in a total of 20 high-risk and 20 low-risk tumors. EP score and MammaPrint score were significantly correlated (p = 0.008). Twelve of 20 samples classified as low-risk by MammaPrint were also low-risk by EP score (60%). 17 of 20 MammaPrint high-risk tumors were also high-risk by EP score. The overall concordance between EP score and MammaPrint was 72.5% (? = 0.45, (95% CI, 0.182 to 0.718)). EPclin score also correlated with MammaPrint results (p = 0.004). Discrepancies between both tests occurred in 10 cases: 5 MammaPrint low-risk patients were classified as EPclin high-risk and 5 high-risk MammaPrint were classified as low-risk by EPclin and overall concordance of 75% (? = 0.5, (95% CI, 0.232 to 0.768)).This pilot study demonstrates a limited concordance between MammaPrint and EndoPredict. Differences in results could be explained by the inclusion of different gene sets in each platform, the use of different methodology, and the inclusion of clinicopathological parameters, such as tumor size and nodal status, in the EndoPredict test.

Keywords
7-dehydrocholesterol reductaseAdipokinesAzgp1 protein, humanBirc5 protein, humanBreast neoplasmsCalcium-binding proteinsCalm2 protein, humanCalmodulinCarrier proteinsCytokine receptor gp130Extracellular matrix proteinsFemaleGlycoproteinsGood health and well-beingHumansIl6st protein, humanImmunohistochemistryIn vitro techniquesInhibitor of apoptosis proteinsIntercellular signaling peptides and proteinsKi-67 antigenMatrix gla proteinMiddle agedOrnithine decarboxylase antizymeOxidoreductases acting on ch-ch group donorsProteinsReceptor, erbb-2Receptors, estrogenReceptors, progesteroneRibosomal proteinsRpl37a protein, humanStc2 protein, humanSurvivinUbe2c protein, humanUbiquitin-conjugating enzymes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLoS ONE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 15/64, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.92, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-06, the following number of citations:

  • WoS: 11
  • Scopus: 12
  • Europe PMC: 4
  • OpenCitations: 11
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 49.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 49 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 13.35.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/681149
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 47% according to the mBERT algorithm developed by Aurora University.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (HARDISSON HERNAEZ, DAVID ALONSO).

the authors responsible for correspondence tasks have been GOENAGA SANCHEZ, AMAIA, SACRISTAN ROMERO, FRANCISCO, ZAMORA AUÑON, MARIA DEL PILAR, SANCHEZ MENDEZ, JOSE IGNACIO, ESPINOSA ARRANZ, ENRIQUE, REDONDO SANCHEZ, ANDRES, FELIU BATLLE, JAIME and HARDISSON HERNAEZ, DAVID ALONSO.