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Analysis of institutional authors

Perez Gomez M.v.Author

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January 13, 2026
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Diagnosis, management and treatment of the Alport syndrome - 2024 guideline on behalf of ERKNet, ERA and ESPN

Publicated to: Nephrology Dialysis Transplantation. 40 (6): 1091-1106 - 2025-06-01 40(6), DOI: 10.1093/ndt/gfae265

Authors:

Torra R; Lipska-Zietkiewicz B; Acke F; Antignac C; Becker JU; Cornec-Le Gall E; Van Eerde AM; Feltgen N; Ferrari R; Gale DP; Gear S; Gross O; Haeberle S; Heidet L; Lennon R; Massella L; Pfau K; Pizarro MdPV; Topaloglu R; Wlodkowski T; Zealey H; Ailioaie O; Aksenova M; Barany P; Barua M; Benetti E; Bonebrake L; Bonny O; Bouts A; Boyer O; Caridi G; Castro-Alonso C; Claes K; Conlon P; Costea GC; Decramer S; Deltas C; Demir E; Demoulin N; Eijgelsheim M; Emma F; Flinter F; Furlano M; Galešić Ljubanović D; Gillion V; Gomes AM; Haffner D; Hoefele J; Jovicic Pavlovic S; Kashtan C; Kohl S; Konrad M; Kopač M; Lemoine S; Liebau MC; Lugani F; Madrid A; Mallett A; Mastrangelo A; Meglič A; Meijer E; Miner J; Mlr S; Ng KH; Oliveira JP; Perez Gomez MV; Pinto AM; Raes A; Rheault M; Savige J; Schwarz C; Sevillano Prieto AM; Tantisattamo E; Tasic V; Tory K; Turner N; Weinstock A; Zakrocka I
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Affiliations

Gdanski Uniwersytet Medyczny; Gdanski Uniwersytet Medyczny - Author
Hacettepe Universitesi - Author
Hopital Necker Enfants Malades - Author
Institute of Molecular and Clinical Ophthalmology Basel - Author
International Alport Syndrome Alliance and Alport UK, - Author
IRCCS Ospedale Pediatrico Bambino Gesu - Author
Italian Association of Alport Syndrome,(ASAL) - Author
l'Institut des Maladies Génétiques Imagine - Author
Royal Manchester Children's Hospital - Author
Uniklinik Koln - Author
Universitair Ziekenhuis Gent - Author
Universitat Autònoma de Barcelona - Author
Universitatsklinikum Heidelberg - Author
Universitatsmedizin Gottingen - Author
Universitatsspital Basel - Author
Universite de Bretagne Occidentale - Author
University College London - Author
University Medical Center Utrecht - Author
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Abstract

Glomerular nephropathy resulting from the genetic defects in COL4A3/4/5 genes including the classical Alport syndrome is the second most common hereditary kidney disease characterized by persistent haematuria progressing to the need for kidney replacement therapy, frequently associated with sensorineural deafness, and occasionally with ocular anomalies. Diagnosis and management of COL4A3/4/5 glomerulopathy is a great challenge due to its phenotypic heterogeneity, multiple modes of inheritance, variable expressivity, and disease penetrance of individual variants as well as imperfect prognostic and progression factors and scarce and limited clinical trials, especially in children. As a joint initiative of the European Rare Kidney disease reference Network (ERKNet), European Renal Association (ERA Genes&Kidney), and European Society for Paediatric Nephrology (ESPN) Inherited renal disorders working group, a team of ex- perts including adult and paediatric nephrologists, kidney geneticists, audiologists, ophthalmologists, and a kidney pathologist were selected to perform a systematic literature review on 21 clinically relevant PICO (Patient or Population covered, Intervention, Com-parator, Outcome) questions. The experts formulated recommendations and formally graded them at a consensus meeting with input from patient representatives and a voting panel of nephrologists representing all regions of the world. Genetic diagnostics comprising joint analysis of COL4A3/4/5 genes is already the key diagnostic test during the initial evaluation of an individual presenting with persistent haematuria, proteinuria, kidney failure of unknown origin, focal segmental sclerosis of unknown origin, and possibly cystic kidney disease. Early renin-angiotensin system blockade is the standard of care therapy; sodium-glucose cotransporter-2 inhibitors may be added in adults with proteinuria and chronic kidney disease. Relatives with heterozygous COL4A3/4/5 variants should only be considered as the last possible resource for living kidney donation. This guideline provides guidance for the diagnosis and management of individuals with pathogenic variants in COL4A3/4/5 genes.
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Keywords

Alport syndromeCol4a3/4/5Collagen ivGlomerular basement membraneHaematuria

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NEPHROLOGY DIALYSIS TRANSPLANTATION due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 3/31, thus managing to position itself as a Q1 (Primer Cuartil), in the category Transplantation. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-04:

  • Scopus: 14
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 37.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 37 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 142.
  • The number of mentions on the social network X (formerly Twitter): 110 (Altmetric).
  • The number of mentions on Wikipedia: 1 (Altmetric).
  • The number of mentions in news outlets: 10 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Belgium; France; Germany; Gran Bretanya; Italy; Netherlands; Poland; Switzerland; Turkey; United Kingdom.

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