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Analysis of institutional authors

Lassaletta A.Author

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January 3, 2026
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Article
Hybrid Gold

Salvage therapies for first relapse of SHH medulloblastoma in early childhood

Publicated to: Neuro-Oncology. 27 (8): 2158-2169 - 2025-08-01 27(8), DOI: 10.1093/neuonc/noaf092

Authors:

Erker C; Mynarek M; Simbozel M; Craig BT; Harrod VL; Cappellano AM; Cohen KJ; Lopez VSM; Morales La Madrid A; Cacciotti C; Baroni L; Salloum R; Margol AS; Michaiel G; Aguilera D; Mazewski CM; Kline CN; Finlay JL; Abdelbaki MS; Murray JC; Dorris K; Crooks B; Ginn KF; Amayiri N; Tippelt S; Fleischhack G; Tonn S; Gerber NU; Lassaletta A; Hansford JR; Khan S; Gilheeney SW; Hoffman LM; Zapotocky M; Larouche V; Shah S; Ramaswamy V; Gajjar A; Perreault S; Mueller S; Hukin J; Cheng S; Wang ZJ; Matheson K; Bailey S; Bouffet E; Clifford SC; Robinson G; Dufour C; Rutkowski S; Lafay-Cousin L
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Affiliations

Alberta Children's Hospital - Author
Children's Mercy Hospitals and Clinics - Author
CHU Sainte-Justine - Le centre hospitalier universitaire mere-enfant - Author
Cook Children's Medical Center - Author
Cumming School of Medicine - Author
Dalhousie University - Author
Division of Hematology Oncology - Author
Emory University - Author
Fakultni Nemocnice v Motole - Author
Hospital de Pediatria SAMIC Prof. Dr. Juan P. Garrahan - Author
Hospital Infantil Universitario Niño Jesús - Author
Hospital Sant Joan de Déu Barcelona - Author
Institut de Cancerologie Gustave Roussy - Author
Keck School of Medicine of USC - Author
Kinderspital Zurich - Author
King Hussein Cancer Center - Author
Newcastle University - Author
Nova Scotia Health Authority - Author
Phoenix Children's Hospital - Author
St. Jude Children's Research Hospital - Author
The Children's Hospital of Philadelphia - Author
The Hospital for Sick Children - Author
The Ohio State University - Author
The Ohio State University College of Medicine - Author
The Sidney Kimmel Comprehensive Cancer Center - Author
The University of Adelaide; University of Melbourne - Author
The University of British Columbia - Author
The University of Texas at Austin - Author
The University of Texas at San Antonio - Author
Universidade Federal de São Paulo - Author
Universität Zürich; UCSF School of Medicine - Author
Universitätsklinikum Essen - Author
Universitätsklinikum Hamburg-Eppendorf - Author
Universitätsklinikum Hamburg-Eppendorf; Universitätsklinikum Hamburg-Eppendorf - Author
Universite Laval - Author
University of Colorado Anschutz School of Medicine - Author
Virginia Commonwealth University - Author
Washington University School of Medicine in St. Louis - Author
Western University - Author
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Abstract

Background Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood medulloblastoma (iMB) and has no standard of care at relapse. This work aimed to evaluate the post-relapse survival (PRS) and explore prognostic factors of patients with nodular desmoplastic (ND) and/or SHH iMB. Methods This international retrospective study included 147 subjects diagnosed with relapsed ND/SHH iMB between 1995 and 2017, <6 years old at original diagnosis, and treated without initial craniospinal irradiation (CSI). Univariable and multivariable Cox models with propensity score analyses were used to assess PRS for those in the curative intent cohort. Results The 3-year PRS was 61.6% (95% confidence interval [CI], 52.2-69.6). The median age at relapse was 3.4 years (interquartile range [IQR], 2.6-4.1). Those with local relapse (40.8%) more often received salvage treatment with surgery (P<.001), low-dose CSI (≤24 Gy; P<.001), or focal radiotherapy (P=.008). Patients not receiving CSI (40.5%) more often received salvage marrow-ablative chemotherapy (HDC + AuHCR [P<.001]). On multivariable analysis, CSI was associated with improved survival (hazard ratio [HR] 0.33 [95% CI, 0.13-0.86], P=.04). Salvage HDC + AuHCR, while clinically important, did not reach statistical significance (HR 0.24 [95% CI, 0.0054-1.025], P=.065). Conclusions Survival of patients with relapsed SHH iMB is not satisfactory and relies on treatments associated with toxicities including CSI and/or HDC + AuHCR. Cure at initial diagnosis to avoid relapse is crucial. For patients with localized relapse undergoing resection, alternative salvage regimens that avoid high-dose CSI (>24 Gy) can be considered.
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Keywords

Infant and early childhoodMedulloblastomaRelapseShh

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neuro-Oncology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 4/286, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-04:

  • Scopus: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 1.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina; Australia; Brazil; Canada; Czech Republic; France; Germany; Gran Bretanya; Jordan; Switzerland; United Kingdom; United States of America.

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