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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Diez Tejedor, ExuperioAuthorDe Lecinana, Maria AlonsoAuthorFuentes, BlancaAuthor

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December 3, 2025
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Keeping prior anticoagulation treatment in the acute phase of ischaemic stroke: the REKOALA study

Publicated to: Journal Of Neurology. 271 (6): 3702-3707 - 2024-06-01 271(6), DOI: 10.1007/s00415-024-12204-8

Authors:

Rigual, R; Rodríguez-Pardo, J; Lorenzo-Diéguez, M; Fernández-Fernández, S; Iglesias, GT; Lastras, C; Ruiz-Ares, G; de Leciñana, MA; de Celis, E; Casado-Fernández, L; Hervás, C; Alonso, E; Díez-Tejedor, E; Fuentes, B
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Affiliations

Paz Univ Hosp, La Paz Univ Hosp, Hosp La Paz Inst Hlth Res IdiPAZ, Dept Neurol, Madrid, Spain - Author
Paz Univ Hosp, La Paz Univ Hosp, Hosp La Paz Inst Hlth Res IdiPAZ, Dept Radiol, Madrid, Spain - Author
Univ Autonoma Madrid, La Paz Univ Hosp, Hosp La Paz Inst Hlth Res IdiPAZ, Stroke Ctr, Madrid, Spain - Author
Univ Autonoma Madrid, Madrid, Spain - Author
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Abstract

Introduction: A consensus on the management of anticoagulated patients in the acute phase of ischaemic stroke has not yet been established. We aimed to evaluate clinical outcomes in such patients based on the continuation or discontinuation of anticoagulation. Methods: Retrospective study of patients with acute ischaemic stroke and cardioembolic source receiving anticoagulant therapy is done. Patients were classified based on the continuation or discontinuation of anticoagulation at admission. Clinical outcomes, haemorrhagic and ischaemic events were assessed. Multivariate logistic regression analysis, propensity score matching (PSM) analysis and a sub-analysis of patients with severe ischaemic stroke at admission (NIHSS score >= 15) were performed. Results: Anticoagulation was continued in 147 (78.8%) of 186 patients. Patients continuing anticoagulant had lower NIHSS (median 5 vs 18, p < 0.001). There were no differences in haemorrhagic or ischaemic events. In the multivariate analysis, good functional outcome at discharge was higher in the continuation group, OR (CI95%) 3.77 (1.2-11.2). PSM analysis adjusted for potential confounders such as NIHSS had higher rates of good functional outcomes at discharge (80% vs 36%, p = 0.004) and at 90 days (76% vs 44%, p = 0.042) in the continuation group. Patients with severe stroke in this group had lower 90-day mortality (34.6% vs 62.5%, p = 0.045) and higher rates of good clinical outcome at discharge (33.3% vs 8.3%, p = 0.032). No differences were observed in 90-day haemorrhagic or ischaemic events. Conclusion: Continuation of anticoagulation in patients with acute ischaemic stroke and cardioembolic source did not increase the risk of intracranial haemorrhage and may be associated with better functional outcomes.
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Keywords

Acute ischaemic strokeAgedAged, 80 and overAnticoagulant therapyAnticoagulantsAtrial-fibrillationCardioembolic strokeContinuing anticoagulant therapyEarly recurrenceFemaleGood health and well-beingHaemorrhagic riskHumansIschemic strokeMaleMiddle agedRetrospective studiesStroke recurrenceTherapyTreatment outcome

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF NEUROLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 40/286, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • WoS: 2
  • Europe PMC: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 87% according to the mBERT algorithm developed by Aurora University.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rigual, Ricardo) and Last Author (FUENTES GIMENO, BLANCA EULALIA).

the author responsible for correspondence tasks has been Rigual, Ricardo.

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Awards linked to the item

We greatly appreciate the support of Morote Traducciones for their assistance in editing this article.
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