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Analysis of institutional authors

Ruiz-Medrano, JorgeCorresponding AuthorRuiz-Moreno, Jose MAuthor

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September 19, 2025
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Biomarkers of risk of switching to dexamethasone implant for the treatment of diabetic macular oedema in real clinical practice: a multicentric study

Publicated to: British Journal Of Ophthalmology. - 2025-05-16 109(10), DOI: 10.1136/bjo-2024-325665

Authors:

Ruiz-Medrano, Jorge; Udaondo Mirete, Patricia; Fernandez-Jimenez, Marina; Asencio-Duran, Monica; Fernandez-Vigo, Jose Ignacio; Medina-Baena, Marta; Flores-Moreno, Ignacio; Pareja-Esteban, Jesus; Touhami, Sara; Giocanti-Auregan, Audrey; Cicinelli, Maria Vittoria; Loewenstein, Anat; Ruiz-Moreno, Jose M
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Affiliations

Avicenne Hosp, Hosp Avicenne, Ophthalmol, Bobigny, France - Author
Castilla La Mancha Univ, Dept Ophthalmol, Albacete, Spain - Author
Castilla La Mancha Univ, Ophthalmol, Albacete, Spain - Author
Clin Rementeria, Madrid, Spain - Author
Ctr Int Oftalmol Avanzada, Ophthalmol, Madrid, Spain - Author
Hop Univ Pitie Salpetriere Charles Foix, Paris, France - Author
Hosp Univ Clin San Carlos, Ophthalmol, Madrid, Spain - Author
Hosp Univ La Fe, Ophthalmol Dept, Valencia, Spain - Author
Hosp Univ Puerta Hierro Majadahonda, Serv Oftalmol, Madrid, Spain - Author
IdiPAZ, Hosp Univ La Paz, Madrid, Spain - Author
Ocular Microsurg Inst IMO, Madrid, Spain - Author
Puerta Hierro Majadahonda Univ Hosp, Madrid, Spain - Author
Puerta Mar Univ Hosp, Cadiz, Spain - Author
Tel Aviv Med Ctr & Sch Med, Ophthalmol, Tel Aviv, Israel - Author
Univ Vita Salute, San Raffaele Hosp, Dept Ophthalmol, Milan, Italy - Author
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Abstract

Objective To establish the influence of different optical coherence tomography (OCT) biomarkers at baseline treatment on the potential response to anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular oedema (DME).Methods Multicentric, retrospective, case-series study in patients with DME switched to dexamethasone implant injections (DEX-i) after anti-VEGF in real clinical practice. Biomarkers analysed on OCT images at baseline included intraretinal fluid (IRF), subretinal fluid (SRF), disorganisation of retinal inner layers (DRIL), disorganisation of retinal outer layers (DROL), hyperreflective foci (HRF), hyperreflective cystoid walls (HCW), dense intraretinal cyst (DIR) and vitreomacular interface (VMI) abnormalities. DME was classified according to the European School for Advanced Studies in Ophthalmology classification. Patients who were treated with anti-VEGF injections with an adequate response were selected as the control group.Results 275 eyes were analysed in this study; 209 eyes (76.0%) switched from anti-VEGF to DEX-i were compared with 66 control eyes (24.0%). Patients who required switching were statistically older, showed worse initial BCVA and higher CRT. Logistic regression analyses showed that female gender, age, central retinal thickness, type of diabetes, SRF, HCW, DIR and VMI increase the likelihood of switching. The OR regarding the need to switch generated by the presence of two of these three factors (SRF, HCW, VMI) was 48.95. Having all three multiplies it by 4.56x1016.Conclusion If baseline OCT shows two of SRF, HCW and VMI biomarkers at baseline, the risk of failure of anti-VEGF therapy is close to 50%. In the presence at baseline of all three biomarkers, failure of anti-VEGF therapy is almost certain.
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Keywords

Aqueous-humorGrowth-factor therapyHyperreflective fociImagingIntravitreal implantManagementOct biomarkersOptical coherence tomographyPrognosisProtocol iRanibizumab treatmentRetinaVisual-acuity

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal BRITISH JOURNAL OF OPHTHALMOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 15/99, thus managing to position itself as a Q1 (Primer Cuartil), in the category Ophthalmology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-12:

  • WoS: 3
  • Scopus: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 12.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France; Israel; Italy.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (RUIZ MEDRANO, JORGE) and Last Author (RUIZ MORENO, JOSE MARIA).

the author responsible for correspondence tasks has been RUIZ MEDRANO, JORGE.

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