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Analysis of institutional authors

Santoyo, SusanaAuthorReglero, GuillermoAuthorJaime, LauraAuthor

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December 16, 2024
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Comprehensive Study of Sustainable Pressurized Liquid Extractions to Obtain Bioavailable Antioxidant Phenolic Compounds from Grape Seed By-Products

Publicated to: Processes. 12 (11): 2308- - 2024-11-01 12(11), DOI: 10.3390/pr12112308

Authors:

Nieto, JA; Santoyo, S; de Sá, M; Sun, BS; Reglero, G; Jaime, L
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Affiliations

Inst Nacl Invest Agr & Vet IP, Polo Inovacao Dois Portos, P-2565191 Dois Portos, Portugal - Author
Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang 110016, Peoples R China - Author
Univ Autonoma Madrid, IMDEA Food Inst, Inst Madrileno Estudios Avanzados, CEI,UAM,CSIC, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Inst Food Sci Res CIAL, CEI, UAM,CSIC, Madrid 28049, Spain - Author
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Abstract

Few investigations have been conducted to evaluate pressurized liquid extraction (PLE) technology as a sustainable method for the recovery of phenolic compounds of grape seed by-products. In this study, PLE combined with an experimental design was evaluated for optimizing the sustainable extraction of phenolic compounds from grape seed by-products. The solvent ethanol content (X1, 0-100%), temperature (X2, 20-100 degrees C) and time (X3, 1-11 min) were studied as independent experimental factors. Yield, TPC, antioxidant activity and phenolic composition were analyzed as optimized dependent variables. Two optimal extraction conditions at different temperatures (20 degrees C and 100 degrees C) were found, but thermal degradations at 100 degrees C allowed for selecting the optimal condition as 75% ethanol, 11 min and 20 degrees C. The optimal extracts showed high phenolic content (TPC = 350.80 +/- 3.97 mg GAE/g extract) and antioxidant activity (ABTS, 9.31 +/- 0.33 mmol Trolox/g extract), mainly composed of polymeric and mono-oligomeric flavan-3-ols. The digestion process reduced the TPC and antioxidant activity due to the low bioaccessibility of the flavan-3-ols, mainly as catechin, epicatechin and polymeric proanthocyanidin losses during the digestion process. However, increases in the antioxidant activity of the basolateral side (DDPH, 0.061 +/- 0.000 mmol Trolox/g extract) were determined after in vitro transepithelial transport, which is a consequence of bioavailable catechin and epicatechin and reduced amounts of dimer B2, dimer B1, epicatechin gallate and gallic acid. Consequently, PLE combined with hydroalcoholic solvents at a low temperature resulted in a valuable methodology to obtain sustainable extracts from grape seed by-products (contributing to the circular economy), containing bioavailable phenolic compounds, which are able to increase the antioxidant status.
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Keywords

AntioxidantBioactive compoundsBioavailabilityEfficient extractionExperimental designGrape seedsGreen processIn-vitroMetabolisPhenolic compoundPlePressurized liquid extractionProanthocyanidiProanthocyanidinProanthocyanidinsRedSimulated digestionSolvent-extractionSubcritical waterSustainable extractionWhite grape

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Processes due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Chemical Engineering (Miscellaneous). Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Engineering, Chemical.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-03-16:

  • WoS: 6
  • Scopus: 5
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-03-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/718738
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: China; Portugal.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Nieto, Juan Antonio) and Last Author (JAIME DE PABLO, LAURA).

the author responsible for correspondence tasks has been Nieto, Juan Antonio.

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Awards linked to the item

This research was funded by Comunidad Autonoma de Madrid, ALIBIRD, project number P2013/ABI2728.
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