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Project information

ID: H2020-EU.2.1.4.-685474

Fecha inicio

01-06-2016

Fecha fin

30-11-2020


Financing

8 808 363,00 Euros
(Total amount or amount awarded)

More information in

Analysis of institutional authors

Hidalgo Huertas, AurelioResearcherPeropadre Lopez, AnaMember of the work teamAlmendros Gimenez, MarcosMember of the work teamSanchez Costa, MercedesMember of the work teamBravo Villanueva, JorgeMember of the work teamCecchini, Davide AgostinoMember of the work team

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Competitive project

Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics.

Researchers: ORTEGA PLAZA, CARMEN (Miembro del equipo de trabajo); CECCHINI, DAVIDE AGOSTINO (Miembro del equipo de trabajo); BRAVO VILLANUEVA, JORGE (Miembro del equipo de trabajo); SANCHEZ COSTA, MERCEDES (Miembro del equipo de trabajo); Almendros Gimenez, Marcos (Miembro del equipo de trabajo); Peropadre Lopez, Ana (Miembro del equipo de trabajo); Nejda Hamdoun, Nargisse (Miembro del equipo de trabajo); Hidalgo Huertas, Aurelio (Investigador/a)

Affiliations

UAM. Facultad de Ciencias. Biología (University Department)
UAM. Facultad de Ciencias. Biología Molecular (University Department)
UAM. Programa de Doctorado en Microbiología (Doctorate Program)
UAM. Programa de Doctorado en Biociencias Moleculares (Doctorate Program)
UAM. Nuevas metodologías de evaluación de riesgos químicos aplicables a la salud humana y ambiental / New approach methodologies for human and environmental chemical risk assessment. (Group)
UAM. Biotecnología Y Genética De Microorganismos Extremófilos (Group)
UAM. Instituto Universitario de Biología Molecular (R & D Center)
UAM. Facultad de Ciencias. Biología (University Department)
UAM. Facultad de Ciencias. Biología Molecular (University Department)
Departamento de Biología Molecular. Centro de Biología Molecular “Severo Ochoa” (Dpt./cen./etc.)
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Abstract

Metagenomes comprise enormous reservoirs coding for proteins with useful activities. Unfortunately, harvesting this reservoir is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Screening campaigns of metagenomic libraries thus require massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and available to very few users. To enable valorisation of the potential of the metagenome, this project assembles an interdisciplinary and intersectoral consortium that will integrate a range of technologies into a platform designed to beat the odds of identifying library hits faster, more efficiently and by a wider user base. Exploration and exploitation of the metagenome will be made faster and more successful by (i) ultrahigh-throughput screening in picoliter droplets that dramatically lowers the cost per assay to well below 0.01 cents and allows throughput of 10e7 assays per hour; (ii) workflows that streamline and increas

Keywords

BioremediationEnzymesMicrobiologyMicrofluidicsSoftware

Financing

Quality index

Call

Metagenomics as innovation driver; INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology

Financer

H2020

Reach

Unión Europea

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