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This research was supported by CONACYT (Mexico) grants 302979 and A1-S-9005 to R.M.D.A. However, the funders had no role in study design, data collection, analysis, publication decision, or manuscript preparation. The APC (Article Processing Charge) was partially funded by the PAIPC (Programa de apoyo e incentivos a publicaciones cientifcas, acronyms in Spanish) program of CONFIE (Coordinacion General para el Fomento a la Investigacion Cientifca e Innovacion del Estado de Sinaloa) and Sociedad Mexicana de Virologia (SMV).

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September 13, 2024
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Antiviral Effect of Microalgae Phaeodactylum tricornutum Protein Hydrolysates against Dengue Virus Serotype 2

Publicated to:Marine Drugs. 22 (8): 369- - 2024-08-01 22(8), DOI: 10.3390/md22080369

Authors: Rivera-Serrano, Bianca Vianey; Cabanillas-Salcido, Sandy Lucero; Cordero-Rivera, Carlos Daniel; Jimenez-Camacho, Ricardo; Norzagaray-Valenzuela, Claudia Desiree; Calderon-Zamora, Loranda; De Jesus-Gonzalez, Luis Adrian; Reyes-Ruiz, Jose Manuel; Farfan-Morales, Carlos Noe; Romero-Utrilla, Alejandra; Ruiz-Ruelas, Victor Manuel; Camberos-Barraza, Josue; Camacho-Zamora, Alejandro; De la Herran-Arita, Alberto Kousuke; Angulo-Rojo, Carla; Guadron-Llanos, Alma Marlene; Rabago-Monzon, Angel Radames; Perales-Sanchez, Janitzio Xiomara Korina; Valdez-Flores, Marco Antonio; Del Angel, Rosa Maria; Osuna-Ramos, Juan Fidel

Affiliations

Autonomous Univ Sinaloa, Fac Biol, Culiacan 80019, Mexico - Author
Autonomous Univ Sinaloa, Fac Chem Biol Sci, Bioproc Lab, Culiacan 80246, Mexico - Author
Autonomous Univ Sinaloa, Fac Med, Culiacan 80246, Mexico - Author
Ctr Res & Adv Studies CINVESTAV IPN, Dept Infectom & Mol Pathogenesis, Mexico City 07360, Mexico - Author
Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Adolfo Ruiz Cortines, Hosp Especial 14, Unidad Med Alta Especialidad, Veracruz 91897, Mexico - Author
Inst Mexicano Seguro Social IMSS, Dept Anat Patol, Culiacan, Mexico - Author
Inst Mexicano Seguro Social IMSS, Unidad Invest Biomed Zacatecas, Zacatecas 98000, Zacatecas, Mexico - Author
Univ Autonoma Metropolitana UAM, Dept Ciencias Nat, Unidad Cuajimalpa, Ciudad De Mexico 05348, Mexico - Author
Univ Autonoma Sinaloa UAS, Fac Med, Programa Doctorado Ciencias Biomed Mol, Culiacan 80246, Mexico - Author
Univ Autonoma Sinaloa UAS, Fac Med, Programa Maestria Ciencias Biomed Mol, Culiacan 80246, Mexico - Author
Univ Autonoma Sinaloa UAS, Fac Med, Programa Maestria Ciencias Med Traslac & Salud Pub, Culiacan 80246, Mexico - Author
Univ Veracruzana, Fac Med, Reg Veracruz, Veracruz 91700, Mexico - Author
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Abstract

Dengue, caused by the dengue virus (DENV), is a global health threat transmitted by Aedes mosquitoes, resulting in 400 million cases annually. The disease ranges from mild to severe, with potential progression to hemorrhagic dengue. Current research is focused on natural antivirals due to challenges in vector control. This study evaluates the antiviral potential of peptides derived from the microalgae Phaeodactylum tricornutum, known for its bioactive compounds. Microalgae were cultivated under controlled conditions, followed by protein extraction and hydrolysis to produce four peptide fractions. These fractions were assessed for cytotoxicity via the MTT assay and antiviral activity against DENV serotype 2 using flow cytometry and plaque formation assays. The 10-30 kDa peptide fraction, at 150 and 300 mu g/mL concentrations, demonstrated no cytotoxicity and significantly reduced the percentage of infected cells and viral titers. These findings suggest that peptides derived from Phaeodactylum tricornutum exhibit promising antiviral activity against dengue virus serotype 2, potentially contributing to developing new therapeutic approaches for dengue.

Keywords

AedesAgentAnimalsAntioxidantAntiviralAntiviral agentsChlorocebus aethiopsDengueDengue virusDenvExtractionHumansMicroalgaePeptidesPhaeodactylum tricornutuPhaeodactylum tricornutumProtein hydrolysatesSerogroupVero cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Marine Drugs due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 14/72, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-08:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Mexico.