Indexado en

Licencia y uso

Citaciones

Cited 17 times in

Altmetrics

Grant support

This research was partially funded by an unlimited grant from Abbott Laboratories SA (Spain). Ignacio Ruiz-Garcia is the recipient of a Rio Hortega grant CM20/00225 from the Instituto de Salud Carlos III and co-funded by Fondo Social Europeo 2014-2020. This research was funded by the Junta de Andalucia (PI-0268-2019). V.C.-B. is funded by postdoctoral fellowships from the Junta de Andalucia (RH-0141-2020).

Análisis de autorías institucional

Compartir

CT-Determined Sarcopenia in GLIM-Defined Malnutrition and Prediction of 6-Month Mortality in Cancer Inpatients

Publicado en:Nutrients. 13 (8): 2647- - 2021-08-01 13(8), DOI: 10.3390/nu13082647

Autores: Sanchez-Torralvo, Francisco Jose; Ruiz-Garcia, Ignacio; Contreras-Bolivar, Victoria; Gonzalez-Almendros, Inmaculada; Ruiz-Vico, Maria; Abuin-Fernandez, Jose; Barrios, Manuel; Alba, Emilio; Olveira, Gabriel;

Afiliaciones

Resumen

Our objective was to evaluate the clinical application of third lumbar vertebra (L3)-computer tomography (CT)-determined sarcopenia as a marker of muscle mass in cancer inpatients diagnosed with malnutrition according to the Global Leadership Initiative on Malnutrition (GLIM) criteria and to establish its association with 6-month mortality. Methods: This was an observational, prospective study in patients from an inpatient oncology unit. We performed a nutritional assessment according to GLIM criteria, including muscle cross-sectional area at L3 by CT and skeletal muscle index (SMI). Six-month mortality was evaluated. Results: A total of 208 patients were included. The skeletal muscle cross-sectional area at L3 was 136.2 +/- 32.5 cm(2) in men and 98.1 +/- 21.2 cm(2) in women. The SMI was 47.4 +/- 12.3 cm(2)/m(2) in men and 38.7 +/- 8.3 cm(2)/m(2) in women. Sarcopenia (low SMI) was detected in 59.6% of the subjects. Using SMI as a marker of low muscle mass in application of GLIM criteria, we found 183 (87.9%) malnourished patients. There were 104 deaths (50%) at 6 months. The deceased patients had a lower skeletal muscle cross-sectional area (112.9 +/- 27.9 vs. 126.1 +/- 37.8 cm(2); p = 0.003) and a lower SMI (41.3 +/- 9.5 vs. 45.7 +/- 12.9 cm(2)/m(2); p = 0.006). An increased risk of 6-month mortality was found in malnourished patients according to GLIM criteria using SMI (HR 2.47; 95% confidence interval 1.07-5.68; p = 0.033). Conclusions: Low muscle mass, assessed by L3-CT, was observed to affect more than half of cancer inpatients. The deceased patients at 6 months had a lower skeletal muscle cross-sectional area and SMI. Malnutrition according to GLIM criteria using CT-determined sarcopenia was shown to adequately predict 6-month mortality.

Palabras clave