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Psychomotor development in infants following maternal exposure to biologics: Results from the DUMBO registry.

Publicado en:Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. (): S1542-3565(25)00488-4 - 2025-06-01 (), DOI: 10.1016/j.cgh.2025.05.012

Autores: Palomino L; Rodríguez-Belvís MV; Casanova MJ; Leo-Carnerero E; Suarez CC; Rivero M; Calvo M; Arroyo MT; Fernández-Clotet A; Pérez-Martínez I; González ÁM; Hernández V; Ruiz-Cerulla A; Serrano PL; Vega P; Rodríguez-Lago I; Lidón RV; De Jorge MÁ; Guerra I; García LA; Arriero GM; Cruz DH; Busquets D; Casbas AG; Van Domselaar M; Gomis GV; Vázquez Morón JM; Cano MP; Lucendo AJ; Martín Arranz MD; Ramírez de la Piscina P; Tirado MDPM; Alonso VR; Pedrosa SM; Camero RC; Gonzalez EA; Marín CT; Martín EB; Rodríguez Grau MC; Huguet JM; Márquez-Mosquera L; Rumbeu PS; Bujanda L; Castaño-Milla C; Arnau ES; Hernández L; Ramos L; Boscá-Watts MM; Marcos NM; Sans M

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Background and aimsThe impact of biologic treatment for inflammatory bowel disease (IBD) during pregnancy and lactation on infant psychomotor development is barely studied. We investigated the effect of exposure to biologics in utero or during breastfeeding on the psychomotor development of offspring during their first year METHODS: The study included patients and infants from DUMBO, an ongoing prospective, observational registry of GETECCU enrolling pregnant women (aged ≥18 years) with IBD from 60 centers across Spain. Mothers were followed-up at each trimester during pregnancy and after delivery. Psychomotor development of infants was assessed using the Spanish version of the Ages and Stages Questionnaire 3rd edition (ASQ-3™) during the first year of life. An ASQ-3™score below the normal limit in any domain was considered abnormal.ResultsIn total, 352 children born to 343 women were assessed; 134 infants (38.1%) were exposed to biologics during pregnancy and 80 (22.7%) during lactation, including five who were exclusively breastfed. At 12 months, the proportions of infants with normal ASQ-3™ total scores (86% vs 74%; p=0.031) and normal gross motor domain scores (91% vs 81%; p=0.033) were significantly higher in the biologics-exposed versus non-exposed subgroups. Multivariate analysis revealed that preterm birth (OR 0.3; 95% CI 0.1-0.6) and maternal ulcerative colitis (OR 0.5; 95% CI 0.3-0.9) were associated with an increased risk of abnormal ASQ-3™. Other variables, including exposure to biologics in utero, had no impact on ASQ-3™ scores at month 12.ConclusionsExposure to biologics for IBD in utero or during breastfeeding has no negative impact on psychomotor development in infants.

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