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ID: GA 101002715

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Tortosa Manzanares, MariolaInvestigador principal

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Selective Pathways for Carbon-Nitrogen Bond Cleavage

Investigadores/as: Tortosa Manzanares, Mariola (Investigador principal (IP))

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Amines are ubiquitous across natural products, pharmaceuticals, polymers and biomolecules. The number of commercially available amines, from simple to complex, makes them one of the most accessible native functional groups. Therefore, they represent an attractive feedstock for the preparation of functionalized molecules through C-N bond activation. Nature long ago developed protocols to promote oxidative deamination reactions. Inspired by this approach, SCAN (Selective Pathways for CArbon-Nitrogen Bond Cleavage) is designed to open new directions in the field of C-N bond cleavage by unlocking the oxidative deamination pathway. To achieve this goal, the following specific objectives are proposed: 1) Design of redox-active amines capable of undergoing oxidative C-N cleavage. 2) Development of novel oxidative deaminations using photoredox and metallaphotoredox catalysis. 3) Site-selective modifications of peptides through photocatalyzed oxidative deaminations. The successful implementation will allow the us

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