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Fernando Ramasco RuedaAutor o Coautor

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20 de septiembre de 2024
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Potenciales biomarcadores predictores de mortalidad en pacientes COVID-19 en el Servicio de Urgencias

Publicado en: Revista Espanola de Quimioterapia. 33 (4): 267 - 273 - 2020-01-01 33(4), DOI:

Autores:

Natalia F Pascual Gómez; Iván Monge Lobo; Inmaculada Granero Cremades; Angels Figuerola Tejerina; Fernando Ramasco Rueda; Andrés von Wernitz Teleki; Francisco M Arrabal Campos; MÁngeles Sanz de Benito
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Resumen

Objective. Identify which biomarkers performed in the first emergency analysis help to stratify COVID-19 patients according to mortality risk. Method. Observational, descriptive and cross-sectional study performed with data collected from patients with suspected COVID-19 in the Emergency Department from February 24 to March 16, 2020. The univariate and multivariate study was performed to find independent mortality markers and calculate risk by building a severity score. Results. A total of 163 patients were included, of whom 33 died and 29 of them were positive for the COVID-19 PCR test. We obtained as possible factors to conform the Mortality Risk Score age> 75 years ((adjusted OR = 12,347, 95% CI: 4,138-36,845 p = 0.001), total leukocytes> 11,000 cells / mm3 (adjusted OR = 2,649, 95% CI: 0.879-7.981 p = 0.083), glucose> 126 mg / dL (adjusted OR = 3.716, 95% CI: 1.247- 11.074 p = 0.018) and creatinine> 1.1 mg / dL (adjusted OR = 2.566, 95% CI: 0.889- 7.403, p = 0.081) This score was called COVEB (COVID, Age, Basic analytical profile) with an AUC 0.874 (95% CI: 0.816-0.933, p <0.001; Cut-off point = 1 (sensitivity = 89.66 % (95% CI: 72.6% -97.8%), specificity = 75.59% (95% CI: 67.2% -82.8%). A score <1 has a negative predictive value = 100% (95% CI: 93.51% -100%) and a positive predictive value = 18.59% (95% CI: 12.82% -25.59%). Conclusions. Clinical severity scales, kidney function biomarkers, white blood cell count parameters, the total neutrophils / total lymphocytes ratio and procalcitonin are early risk factors for mortality. The variables age, glucose, creatinine and total leukocytes stand out as the best predictors of mortality. A COVEB score <1 indicates with a 100% probability that the patient with suspected COVID-19 will not die in the next 30 days.
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Palabras clave

Ciencias de la saludMedicina clínica

Indicios de calidad

Impacto bibliométrico. Análisis de la aportación y canal de difusión

El trabajo ha sido publicado en la revista Revista Española de Quimioterapia, y aunque la revista se encuentra clasificada en el cuartil Q4 (Agencia WoS (JCR)), su enfoque regional y su especialización en Pharmacology & Pharmacy, le otorgan un reconocimiento lo suficientemente significativo en un nicho concreto del conocimiento científico a nivel internacional.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-09:

  • Dialnet Métricas: 5
  • WoS: 14
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